S128 Highly invasive capsular serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to complement and phagocytosis
Hyams C, Trzcinski K, Weinberger D, Lipsitch M, Brown J. S128 Highly invasive capsular serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to complement and phagocytosis. Thorax 2011, 66: a59. DOI: 10.1136/thoraxjnl-2011-201054b.128.Peer-Reviewed Original ResearchC3b/iC3b depositionNeutrophil associationFH bindingIC3b depositionCapsular serotypesS pneumoniaeSerotype-dependent differencesC3b depositionCertain serotypesFresh human neutrophilsFlow cytometry assayAlternative complement pathwayNasopharyngeal colonisationComplement depositionNeutrophil phagocytosisInvasive serotypesCapsular thicknessComplement activityAlternative pathway activityCytometry assaysInvasive strainsEssential virulence factorFlow cytometryComplement pathwayHIGH FH