The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1
Cornick JE, Bishop Ö, Yalcin F, Kiran AM, Kumwenda B, Chaguza C, Govindpershad S, Ousmane S, Senghore M, du Plessis M, Pluschke G, Ebruke C, McGee L, Sigaùque B, Collard JM, Bentley SD, Kadioglu A, Antonio M, von Gottberg A, French N, Klugman KP, Heyderman RS, Alderson M, Everett DB, consortium F. The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. Vaccine 2017, 35: 972-980. PMID: 28081968, PMCID: PMC5287219, DOI: 10.1016/j.vaccine.2016.12.037.Peer-Reviewed Original ResearchConceptsProtein vaccine candidatePneumococcal protein vaccinesProtein vaccineVaccine candidatesSerotype 1Multi-valent vaccinesSerotype 1 pneumococciPneumococcal conjugate vaccineHuman immune responseImportant pneumococcal serotypesConjugate vaccinePneumococcal diseasePneumococcal serotypesVaccine interventionsCommon causeImmune responseStudy populationAllelic variantsTarget antigenVaccineS. pneumoniae TIGR4Pneumococcal populationIntervention strategiesPCPADifferent allelic variants