2021
Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis
Kalizang'oma A, Chaguza C, Gori A, Davison C, Beleza S, Antonio M, Beall B, Goldblatt D, Kwambana-Adams B, Bentley SD, Heyderman RS. Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from Streptococcus mitis. Microbial Genomics 2021, 7: 000622. PMID: 34550067, PMCID: PMC8715442, DOI: 10.1099/mgen.0.000622.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsBeta-Lactam ResistanceDrug Resistance, BacterialGene Transfer, HorizontalGenes, BacterialHumansMicrobial Sensitivity TestsNasopharynxPenicillin-Binding ProteinsPenicillinsPhylogenyPneumococcal InfectionsPneumococcal VaccinesSerogroupStreptococcusStreptococcus mitisStreptococcus oralisStreptococcus pneumoniaeWhole Genome SequencingConceptsMinimum inhibitory concentrationPneumococcal vaccine programsFirst-line treatmentHigh minimum inhibitory concentrationsStreptococcus pneumoniae serotypesPneumococcal population structurePneumococcal serotypes 6ABeta-lactam antibioticsLonger carriage durationBeta-lactam resistanceImportant global pathogenPneumococcal diseaseBacterial pneumoniaPneumococcal serotypesVaccine programSerotypes 6APneumoniae serotypesΒ-lactam susceptibilityPenicillin-binding protein (PBP) genesHuman nasopharynxCarriage durationCommensal streptococciCommon recipientInhibitory concentrationStreptococci
2017
Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting
Musicha P, Feasey NA, Cain AK, Kallonen T, Chaguza C, Peno C, Khonga M, Thompson S, Gray KJ, Mather AE, Heyderman RS, Everett DB, Thomson NR, Msefula CL. Genomic landscape of extended-spectrum β-lactamase resistance in Escherichia coli from an urban African setting. Journal Of Antimicrobial Chemotherapy 2017, 72: 1602-1609. PMID: 28333330, PMCID: PMC5437524, DOI: 10.1093/jac/dkx058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBeta-Lactam ResistanceBeta-LactamasesChildChild, PreschoolChloramphenicolDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsFemaleGenes, BacterialGenetic VariationGenomicsHumansMalawiMaleMicrobial Sensitivity TestsMultilocus Sequence TypingPhylogenyUrban PopulationYoung AdultConceptsAntimicrobial resistanceExtended spectrum β-lactamase resistanceEscherichia coli infectionResource-rich settingsUrban African settingCommon ESBL geneLow-income settingsPhenotypic resistance profilesΒ-lactamase resistanceColi infectionESBL resistanceGlobal epidemiologyFluoroquinolone resistanceQueen's HospitalBla CTXESBL genesMolecular epidemiologyResistance profilesMolecular patternsAfrican settingClinical sourcesHospitalE. coliEpidemiologyST131