Pneumococcal within-host diversity during colonization, transmission and treatment
Tonkin-Hill G, Ling C, Chaguza C, Salter SJ, Hinfonthong P, Nikolaou E, Tate N, Pastusiak A, Turner C, Chewapreecha C, Frost SDW, Corander J, Croucher NJ, Turner P, Bentley SD. Pneumococcal within-host diversity during colonization, transmission and treatment. Nature Microbiology 2022, 7: 1791-1804. PMID: 36216891, PMCID: PMC9613479, DOI: 10.1038/s41564-022-01238-1.Peer-Reviewed Original ResearchConceptsAntimicrobial treatmentAbsence of treatmentMultidrug-resistant bacteriumNasopharyngeal samplesElevated riskGold standard methodTreatment dataStreptococcus pneumoniaePersistent colonizationPneumococcal populationGenomic surveillanceInter-strain competitionTreatmentDeep sequencingInfantsResistant lineagesElevated ratesBacterial pathogensFirst yearMothersSensitive bacteriaTransmission chainSurveillanceSusceptible lineagesPathogens