2024
Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases
Kalizang’oma A, Richard D, Kwambana-Adams B, Coelho J, Broughton K, Pichon B, Hopkins K, Chalker V, Beleza S, Bentley S, Chaguza C, Heyderman R. Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases. Nature Communications 2024, 15: 7812. PMID: 39242612, PMCID: PMC11379897, DOI: 10.1038/s41467-024-52120-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsBacteremiaDrug Resistance, BacterialEndocarditisEndocarditis, BacterialFemaleGenetic VariationGenome, BacterialGenomicsHumansIrelandMaleMiddle AgedPhylogenyStreptococcal InfectionsStreptococcus mitisUnited KingdomVirulenceVirulence FactorsWhole Genome SequencingConceptsGenetic diversityBloodstream infectionsInvestigate genetic diversityInfective endocarditisStreptococcus mitisPneumococcal virulence genesS. mitisPopulation genomicsInfective endocarditis casesGenome sequenceVirulence genesGenomic epidemiologyCarriage strainsResistant lineagesPathogenic natureIE casesAntimicrobial resistanceEndocarditis casesIE incidenceLineagesGenomeIsolatesPathogensClinicPatients
2022
Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis
Kalizang’oma A, Kwambana-Adams B, Chan J, Viswanath A, Gori A, Richard D, Jolley K, Lees J, Goldblatt D, Beleza S, Bentley S, Heyderman R, Chaguza C. Novel Multilocus Sequence Typing and Global Sequence Clustering Schemes for Characterizing the Population Diversity of Streptococcus mitis. Journal Of Clinical Microbiology 2022, 61: e00802-22. PMID: 36515506, PMCID: PMC9879099, DOI: 10.1128/jcm.00802-22.Peer-Reviewed Original ResearchConceptsSequence clustersPathogenic streptococcal speciesMultilocus sequence typing (MLST) schemePopulation diversitySingle-nucleotide polymorphism distancesSequence typesSequence typing schemeUnique sequence typesGenetic diversityPopulation structureBacterial population diversityMolecular typing toolsS. mitisHousekeeping genesSequence fragmentsMLST schemeDiversityOpportunistic pathogenStreptococcus mitisStreptococcal speciesTyping toolSpeciesNew insightsTyping schemeMultilocus sequence typing