Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes
Bricio-Moreno L, Chaguza C, Yahya R, Shears RK, Cornick JE, Hokamp K, Yang M, Neill DR, French N, Hinton JCD, Everett DB, Kadioglu A. Lower Density and Shorter Duration of Nasopharyngeal Carriage by Pneumococcal Serotype 1 (ST217) May Explain Its Increased Invasiveness over Other Serotypes. MBio 2020, 11: e00814-20. PMID: 33293378, PMCID: PMC7733939, DOI: 10.1128/mbio.00814-20.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseNasopharyngeal carriageSerotype 1Invasive diseaseDisease progressionPneumococcal strainsInvasive pneumococcal disease casesQueen Elizabeth Central HospitalMajor causePneumococcal disease casesPneumococcal serotype 1Health care systemPneumococcal diseaseCentral HospitalVaccine efficacyInvasive infectionsInvasive pneumoniaCommon causeMurine modelMouse modelDisease casesCarrier stateHuman nasopharynxPneumoniaRNA sequencing analysisHypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity
Panagiotou S, Chaguza C, Yahya R, Audshasai T, Baltazar M, Ressel L, Khandaker S, Alsahag M, Mitchell TJ, Prudhomme M, Kadioglu A, Yang M. Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity. Scientific Reports 2020, 10: 17313. PMID: 33057054, PMCID: PMC7560715, DOI: 10.1038/s41598-020-73454-w.Peer-Reviewed Original ResearchConceptsPneumococcal serotype 1Invasive pneumococcal diseaseSerotype 1Haemolytic activityVivo mouse modelDetectable haemolytic activityNeutrophil-mediated phagocytosisPneumococcal diseaseCommon causeInfection doseHuman reservoirMouse modelRapid onsetStreptococcus pneumoniaeDisease symptomsLethal doseClonal typesVirulence propertiesGlobal pathogenST306IgA proteaseSymptomsSequence typesMiceDose