2024
Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases
Kalizang’oma A, Richard D, Kwambana-Adams B, Coelho J, Broughton K, Pichon B, Hopkins K, Chalker V, Beleza S, Bentley S, Chaguza C, Heyderman R. Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases. Nature Communications 2024, 15: 7812. PMID: 39242612, PMCID: PMC11379897, DOI: 10.1038/s41467-024-52120-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsBacteremiaDrug Resistance, BacterialEndocarditisEndocarditis, BacterialFemaleGenetic VariationGenome, BacterialGenomicsHumansIrelandMaleMiddle AgedPhylogenyStreptococcal InfectionsStreptococcus mitisUnited KingdomVirulenceVirulence FactorsWhole Genome SequencingConceptsGenetic diversityBloodstream infectionsInvestigate genetic diversityInfective endocarditisStreptococcus mitisPneumococcal virulence genesS. mitisPopulation genomicsInfective endocarditis casesGenome sequenceVirulence genesGenomic epidemiologyCarriage strainsResistant lineagesPathogenic natureIE casesAntimicrobial resistanceEndocarditis casesIE incidenceLineagesGenomeIsolatesPathogensClinicPatientsGenomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi
Chaguza C, Chibwe I, Chaima D, Musicha P, Ndeketa L, Kasambara W, Mhango C, Mseka U, Bitilinyu-Bangoh J, Mvula B, Kipandula W, Bonongwe P, Munthali R, Ngwira S, Mwendera C, Kalizang’oma A, Jambo K, Kambalame D, Kamng’ona A, Steele A, Chauma-Mwale A, Hungerford D, Kagoli M, Nyaga M, Dube Q, French N, Msefula C, Cunliffe N, Jere K. Genomic insights into the 2022–2023Vibrio cholerae outbreak in Malawi. Nature Communications 2024, 15: 6291. PMID: 39060226, PMCID: PMC11282309, DOI: 10.1038/s41467-024-50484-w.Peer-Reviewed Original ResearchConceptsSerogroup O1 strainsIntegrative conjugative elementsPhylogenetic reconstructionPopulation genomicsGenomic insightsOutbreak isolatesVirulence elementsConjugative elementsO1 strainsVibrio choleraeOutbreak strainEl TorAntimicrobial resistanceCholera outbreaksO1 OgawaIsolatesCholeraStrainCtxB7 genotypesProphageGenomeVirulenceCtxB7SublineagesLineages
2022
Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation
Chaguza C, Smith J, Bruce S, Gibson R, Martin I, Andam C. Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation. Cell Genomics 2022, 2: 100194. PMID: 36465278, PMCID: PMC9718559, DOI: 10.1016/j.xgen.2022.100194.Peer-Reviewed Original ResearchGenome-wide association studiesPopulation genomic studiesBacterial genetic variationMulti-host pathogensSpecific genetic lociGenomic studiesGenetic variationGenetic lociHost infectionAdditional lociAnimal hostsAssociation studiesImmune evasion factorsOverall heritabilityImmune evasion genesGenetic variantsAnimal isolatesLociHuman hostInfection of humansEvasion genesHostKey roleAdaptationIsolatesComparative Genomics of Disease and Carriage Serotype 1 Pneumococci
Chaguza C, Ebruke C, Senghore M, Lo S, Tientcheu P, Gladstone R, Tonkin-Hill G, Cornick J, Yang M, Worwui A, McGee L, Breiman R, Klugman K, Kadioglu A, Everett D, Mackenzie G, Croucher N, Roca A, Kwambana-Adams B, Antonio M, Bentley S. Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci. Genome Biology And Evolution 2022, 14: evac052. PMID: 35439297, PMCID: PMC9048925, DOI: 10.1093/gbe/evac052.Peer-Reviewed Original ResearchConceptsGenomic variationGenome-wide association studiesComparative genomicsGenetic variationLineage distributionAssociation studiesPhenotypic variabilityPathogen surveillanceSystemic tissuesIsolatesSerotype 1GenomicsLineagesGeneticsMinimal effectVariationInvasivenessSerotype 1 pneumococciIsolationInvasive disease
2015
Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome
Kulohoma BW, Cornick JE, Chaguza C, Yalcin F, Harris SR, Gray KJ, Kiran AM, Molyneux E, French N, Parkhill J, Faragher BE, Everett DB, Bentley SD, Heyderman RS. Comparative Genomic Analysis of Meningitis- and Bacteremia-Causing Pneumococci Identifies a Common Core Genome. Infection And Immunity 2015, 83: 4165-4173. PMID: 26259813, PMCID: PMC4567637, DOI: 10.1128/iai.00814-15.Peer-Reviewed Original ResearchConceptsBloodstream infectionsSterile sitesPneumococcal population structureDisease manifestationsMeningitisVaccine candidatesS. pneumoniaeStreptococcus pneumoniaeNasopharyngeal commensalPneumococciVirulence factorsWhole-genome sequencingInfectionPneumoniaeVirulence behaviorPresence/absenceIsolatesMeninges