Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases
Kalizang’oma A, Richard D, Kwambana-Adams B, Coelho J, Broughton K, Pichon B, Hopkins K, Chalker V, Beleza S, Bentley S, Chaguza C, Heyderman R. Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases. Nature Communications 2024, 15: 7812. PMID: 39242612, PMCID: PMC11379897, DOI: 10.1038/s41467-024-52120-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Bacterial AgentsBacteremiaDrug Resistance, BacterialEndocarditisEndocarditis, BacterialFemaleGenetic VariationGenome, BacterialGenomicsHumansIrelandMaleMiddle AgedPhylogenyStreptococcal InfectionsStreptococcus mitisUnited KingdomVirulenceVirulence FactorsWhole Genome SequencingConceptsGenetic diversityBloodstream infectionsInvestigate genetic diversityInfective endocarditisStreptococcus mitisPneumococcal virulence genesS. mitisPopulation genomicsInfective endocarditis casesGenome sequenceVirulence genesGenomic epidemiologyCarriage strainsResistant lineagesPathogenic natureIE casesAntimicrobial resistanceEndocarditis casesIE incidenceLineagesGenomeIsolatesPathogensClinicPatients