2017
The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1
Cornick JE, Bishop Ö, Yalcin F, Kiran AM, Kumwenda B, Chaguza C, Govindpershad S, Ousmane S, Senghore M, du Plessis M, Pluschke G, Ebruke C, McGee L, Sigaùque B, Collard JM, Bentley SD, Kadioglu A, Antonio M, von Gottberg A, French N, Klugman KP, Heyderman RS, Alderson M, Everett DB, consortium F. The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. Vaccine 2017, 35: 972-980. PMID: 28081968, PMCID: PMC5287219, DOI: 10.1016/j.vaccine.2016.12.037.Peer-Reviewed Original ResearchConceptsProtein vaccine candidatePneumococcal protein vaccinesProtein vaccineVaccine candidatesSerotype 1Multi-valent vaccinesSerotype 1 pneumococciPneumococcal conjugate vaccineHuman immune responseImportant pneumococcal serotypesConjugate vaccinePneumococcal diseasePneumococcal serotypesVaccine interventionsCommon causeImmune responseStudy populationAllelic variantsTarget antigenVaccineS. pneumoniae TIGR4Pneumococcal populationIntervention strategiesPCPADifferent allelic variants
2015
Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae
Chaguza C, Cornick JE, Everett DB. Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae. Computational And Structural Biotechnology Journal 2015, 13: 241-247. PMID: 25904996, PMCID: PMC4404416, DOI: 10.1016/j.csbj.2015.03.007.Peer-Reviewed Original ResearchGenetic recombinationWhole-genome sequence dataKey evolutionary mechanismGenome sequence dataPopulation geneticsEvolutionary mechanismsGenetic variationSequence dataExogenous DNASelective pressureSpontaneous mutationsHuman diseasesEvolution studiesPneumococcal adaptationRecombinationAdaptive immune responsesComputational toolsGenomeEvolutionGeneticsOrganismsImmune responseRapid influxDNABacterium