C-Reactive Protein Testing for Active Tuberculosis among Inpatients without HIV in Uganda: a Diagnostic Accuracy Study
Meyer AJ, Ochom E, Turimumahoro P, Byanyima P, Sanyu I, Lalitha R, Kaswabuli S, Andama A, Walter ND, Katamba A, Cattamanchi A, Worodria W, Huang L, Yoon C, Davis JL. C-Reactive Protein Testing for Active Tuberculosis among Inpatients without HIV in Uganda: a Diagnostic Accuracy Study. Journal Of Clinical Microbiology 2020, 59: 10.1128/jcm.02162-20. PMID: 33087439, PMCID: PMC7771459, DOI: 10.1128/jcm.02162-20.Peer-Reviewed Original ResearchMeSH KeywordsC-Reactive ProteinCross-Sectional StudiesHIV InfectionsHumansInpatientsMycobacterium tuberculosisProspective StudiesSensitivity and SpecificitySputumTuberculosisUgandaConceptsC-reactive proteinEnzyme-linked immunosorbent assayTriage testUtility of CRPC-reactive protein testingCulture-positive pulmonary tuberculosisProspective cross-sectional studySerum C-reactive proteinDiagnostic performanceHIV-seronegative individualsTB triage testNational Referral HospitalCross-sectional studyNegative predictive valueNegative likelihood ratioDiagnostic accuracy studiesActive tuberculosisPulmonary tuberculosisTB screeningReferral hospitalIllness severityCRP testingSputum samplesManufacturer's thresholdPredictive valueSputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda
Meyer AJ, Atuheire C, Worodria W, Kizito S, Katamba A, Sanyu I, Andama A, Ayakaka I, Cattamanchi A, Bwanga F, Huang L, Davis JL. Sputum quality and diagnostic performance of GeneXpert MTB/RIF among smear-negative adults with presumed tuberculosis in Uganda. PLOS ONE 2017, 12: e0180572. PMID: 28686705, PMCID: PMC5501569, DOI: 10.1371/journal.pone.0180572.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesFemaleHumansMaleMicroscopyMolecular Diagnostic TechniquesMycobacterium tuberculosisProspective StudiesSputumTuberculosis, PulmonaryUgandaYoung AdultConceptsGeneXpert MTB/RIFBlood-stained sputumSputum qualityMTB/RIFSalivary sputumXpert testingDiagnostic performanceMycobacterial cultureCross-sectional studyTB patientsPatient factorsSputum testTB diagnosisDiagnostic yieldMucoid sputumSputum samplesLED fluorescence microscopySputumXpertTuberculosis diagnosticsDemographic informationPatientsAdditional testingHigher proportionSample types