2021
Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city
Godoy RSM, dos Santos Felix L, da Silva Orfanó A, Chaves BA, Nogueira PM, dos Anjos Costa B, Soares AS, Oliveira CCA, Nacif-Pimenta R, Silva BM, Duarte AP, de Lacerda M, Monteiro WM, Secundino NFC, Pimenta PFP. Dengue and Zika virus infection patterns vary among Aedes aegypti field populations from Belo Horizonte, a Brazilian endemic city. PLOS Neglected Tropical Diseases 2021, 15: e0009839. PMID: 34727099, PMCID: PMC8562804, DOI: 10.1371/journal.pntd.0009839.Peer-Reviewed Original ResearchConceptsViral loadDengue virusZika virusSalivary glandsInfection phaseInfection patternsPublic health systemAegypti field populationsHealth districtArboviral infectionsLate infection phaseInfected personsAedes aegypti field populationsViral infectionEndemic regionsEndemic cityInfection rateInfectionHealth systemMosquito responsesMosquito populationsZika outbreakVirusBlood mealVector competenceParatransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
Yang L, Weiss BL, Williams AE, Aksoy E, de Silva Orfano A, Son JH, Wu Y, Vigneron A, Karakus M, Aksoy S. Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment. PLOS Pathogens 2021, 17: e1009475. PMID: 34107000, PMCID: PMC8216540, DOI: 10.1371/journal.ppat.1009475.Peer-Reviewed Original ResearchConceptsGut lumenCurrent disease control methodsTsetse's PMMidgut environmentTsetse's abilityAbundant secretory proteinsPeritrophic matrixInfection outcomesTrypanosome infection prevalenceChemotherapeutic treatmentParatransgenic manipulationInfected peopleEtiological agentInfection prevalenceInfectionInfection establishmentParasitic African trypanosomesCardiaSignificant increaseNon-coding RNAsPhysiological homeostasisMolecular cascadesBlood digestionSmall non-coding RNAsParatransgenic tsetse
2019
Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni
Nacif-Pimenta R, da Silva Orfanó A, Mosley IA, Karinshak SE, Ishida K, Mann VH, Coelho PMZ, da Costa JMC, Hsieh MH, Brindley PJ, Rinaldi G. Differential responses of epithelial cells from urinary and biliary tract to eggs of Schistosoma haematobium and S. mansoni. Scientific Reports 2019, 9: 10731. PMID: 31341177, PMCID: PMC6656753, DOI: 10.1038/s41598-019-46917-y.Peer-Reviewed Original ResearchConceptsSchistosome eggsEpithelial cellsS. haematobiumS. mansoniUrothelial cellsS. mansoni eggsS. haematobium eggsSquamous cell carcinomaCell proliferative responsesGroup 1 carcinogenHepatointestinal schistosomiasisPeriportal fibrosisBiliary tractMansoni eggsCell carcinomaChronic infectionUrogenital schistosomiasisEstrogen receptorProliferative responseDefinitive causeSchistosoma haematobiumNormal urotheliumHuman epithelial cellsMesenchymal transitionS. japonicumVertical Transmission of Zika Virus (Flaviviridae, Flavivirus) in Amazonian Aedes aegypti (Diptera: Culicidae) Delays Egg Hatching and Larval Development of Progeny
Chaves BA, Vieira A, Silveira KRD, da Costa Paz A, da Costa Vaz E, Araujo RGP, Rodrigues NB, Campolina TB, da Silva Orfano A, Nacif-Pimenta R, Villegas LEM, de Melo F, de Mello Silva B, Monteiro WM, Guerra M, de Lacerda M, Norris DE, Secundino NFC, Pimenta PFP. Vertical Transmission of Zika Virus (Flaviviridae, Flavivirus) in Amazonian Aedes aegypti (Diptera: Culicidae) Delays Egg Hatching and Larval Development of Progeny. Journal Of Medical Entomology 2019, 56: 1739-1744. PMID: 31278737, PMCID: PMC6821368, DOI: 10.1093/jme/tjz110.Peer-Reviewed Original ResearchConceptsZika virusQuantitative polymerase chain reactionEffects of ZIKVZIKV-infected mosquitoesVirus-free colonyZIKV infectionPolymerase chain reactionVirus exposureZIKV transmissionOral infectionZIKV strainsInfectious bloodmealAedes aegyptiControl mosquitoesC6/36 cellsVertical transmissionChain reactionVirusViable virusInfected eggsImportant arbovirusesInfectionEpidemiological roleMosquitoesVT
2012
Schistosoma mansoni in Susceptible and Resistant Snail Strains Biomphalaria tenagophila: In Vivo Tissue Response and In Vitro Hemocyte Interactions
Nacif-Pimenta R, de Mattos AC, da Silva Orfanó A, Barbosa L, Pimenta PF, Coelho PM. Schistosoma mansoni in Susceptible and Resistant Snail Strains Biomphalaria tenagophila: In Vivo Tissue Response and In Vitro Hemocyte Interactions. PLOS ONE 2012, 7: e45637. PMID: 23049828, PMCID: PMC3458097, DOI: 10.1371/journal.pone.0045637.Peer-Reviewed Original ResearchConceptsS. mansoniInternal defense systemNon-self molecular patternsResistant snailsSchistosoma mansoniResistant strainsImmune defense mechanismsBiomphalaria tenagophilaThreat of infectionB. tenagophilaSnail strainsInitial infectionSusceptible snailsParasitic diseasesInfectionImmune defense responseMansoniMolecular patternsSusceptible strainsTissue responseTime courseCellular reactionsHost cellsCellular defenseVivo tissue response