2025
Burden and care time for dementia caregivers in the LIVE@Home.Path trial
Berge L, Angeles R, Gedde M, Fæø S, Mannseth J, Vislapuu M, Puaschitz N, Hillestad E, Aarsland D, Achterberg W, Allore H, Ballard C, Li F, Selbæk G, Vahia I, Husebo B. Burden and care time for dementia caregivers in the LIVE@Home.Path trial. Alzheimer's & Dementia 2025, 21: e14622. PMID: 40042468, PMCID: PMC11881633, DOI: 10.1002/alz.14622.Peer-Reviewed Original ResearchConceptsRelative Stress ScaleInformal care timeCaregiver burdenLiving interventionsCare timeIntervention periodStepped wedge randomized controlled trialVolunteer supportHome-dwelling peopleStepped-wedge trialPersonal activitiesDementia caregiversRandomized controlled trialsIntention-to-treatStress ScaleMunicipal coordinatorCaregiversPersonal supportRandomized dyadsDementiaControlled trialsPrimary outcomeControl periodInterventionPositive changes
2023
Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review
Nicholls S, Al‐Jaishi A, Niznick H, Carroll K, Madani M, Peak K, Madani L, Nevins P, Adisso L, Li F, Weijer C, Mitchell S, Welch V, Quiñones A, Taljaard M. Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12392. PMID: 36777091, PMCID: PMC9899766, DOI: 10.1002/dad2.12392.Peer-Reviewed Original Research
2022
Ethical considerations within pragmatic randomized controlled trials in dementia: Results from a literature survey
Nicholls SG, Carroll K, Nix HP, Li F, Hey SP, Mitchell SL, Weijer C, Taljaard M. Ethical considerations within pragmatic randomized controlled trials in dementia: Results from a literature survey. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2022, 8: e12287. PMID: 35509502, PMCID: PMC9060321, DOI: 10.1002/trc2.12287.Peer-Reviewed Original ResearchEthical considerationsEthical protectionsVulnerable participantsConsent approachResearch participantsResearch participationPatient's capacityAlzheimer's diseaseEthics approvalSearch of MEDLINEHealth care professionalsCapacity assessmentStudy populationEligible reportsTrial settingsConsentVulnerable groupsDementiaTwo-thirdsConsiderationDiseaseTrialsParticipantsExtracted informationMention
2021
Methodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement
Taljaard M, Li F, Qin B, Cui C, Zhang L, Nicholls SG, Carroll K, Mitchell SL. Methodological challenges in pragmatic trials in Alzheimer’s disease and related dementias: Opportunities for improvement. Clinical Trials 2021, 19: 86-96. PMID: 34841910, PMCID: PMC8847324, DOI: 10.1177/17407745211046672.Peer-Reviewed Original ResearchConceptsPragmatic trialAlzheimer's diseasePrimary outcomeSample size calculationGroup treatment trialsPairs of reviewersDementia researchSize calculationCluster Randomized TrialGroup treatment designRandomized trialsTreatment trialsIntracluster correlationMethodological qualityTrial reportsBaseline assessmentDiseaseTrialsDementiaKey methodological characteristicsOutcomesType IMethodological quality indicatorsUnique methodological challengesSame individual
2020
Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia
Allore HG, Goldfeld KS, Gutman R, Li F, Monin JK, Taljaard M, Travison TG. Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia. Journal Of The American Geriatrics Society 2020, 68: s68-s73. PMID: 32589276, PMCID: PMC7396162, DOI: 10.1111/jgs.16616.Peer-Reviewed Original ResearchConceptsEmbedded Pragmatic Clinical TrialsPragmatic clinical trialsClinical trialsAlzheimer's diseaseImbedded Pragmatic Alzheimer's DiseaseIMPACT CollaboratoryOutcome ascertainmentPoint of careNonpharmacological interventionsReal-world settingComplex interventionsTrialsIntervention effectivenessVulnerable populationsPragmatic designHealthcare systemNational InstituteClinical scientistsSuch interventionsInterventionDementiaPLWDDiseaseCaregiversResearch priorities
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