2024
Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM
Khera R, Aminorroaya A, Dhingra L, Thangaraj P, Pedroso Camargos A, Bu F, Ding X, Nishimura A, Anand T, Arshad F, Blacketer C, Chai Y, Chattopadhyay S, Cook M, Dorr D, Duarte-Salles T, DuVall S, Falconer T, French T, Hanchrow E, Kaur G, Lau W, Li J, Li K, Liu Y, Lu Y, Man K, Matheny M, Mathioudakis N, McLeggon J, McLemore M, Minty E, Morales D, Nagy P, Ostropolets A, Pistillo A, Phan T, Pratt N, Reyes C, Richter L, Ross J, Ruan E, Seager S, Simon K, Viernes B, Yang J, Yin C, You S, Zhou J, Ryan P, Schuemie M, Krumholz H, Hripcsak G, Suchard M. Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM. Journal Of The American College Of Cardiology 2024, 84: 904-917. PMID: 39197980, DOI: 10.1016/j.jacc.2024.05.069.Peer-Reviewed Original ResearchConceptsGLP-1 RAsSecond-line agentsGLP-1Antihyperglycemic agentsCardiovascular diseaseMACE riskGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsEffects of SGLT2isType 2 diabetes mellitusPeptidase-4 inhibitorsAdverse cardiovascular eventsCox proportional hazards modelsRandom-effects meta-analysisCardiovascular risk reductionTarget trial emulationProportional hazards model
2022
Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies
Khera R, Schuemie MJ, Lu Y, Ostropolets A, Chen R, Hripcsak G, Ryan PB, Krumholz HM, Suchard MA. Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies. BMJ Open 2022, 12: e057977. PMID: 35680274, PMCID: PMC9185490, DOI: 10.1136/bmjopen-2021-057977.Peer-Reviewed Original ResearchConceptsLarge-scale Evidence GenerationType 2 diabetes mellitusCardiovascular effectivenessDiabetes mellitusSafety outcomesGlucagon-like peptide-1 receptor agonistsSodium-glucose co-transporter-2 inhibitorsMajor adverse cardiovascular eventsNew-user cohort designPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsSafety studiesAdverse cardiovascular eventsPrimary cardiovascular outcomePeptidase-4 inhibitorsAnti-hyperglycaemic agentsElectronic health record data sourcesEvidence generationCardiovascular eventsCardiovascular outcomesCardiovascular riskActive comparatorTherapeutic optionsReceptor agonistDrug comparisons
2016
Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants
Zhou B, Lu Y, Hajifathalian K, Bentham J, Di Cesare M, Danaei G, Bixby H, Cowan M, Ali M, Taddei C, Lo W, Reis-Santos B, Stevens G, Riley L, Miranda J, Bjerregaard P, Rivera J, Fouad H, Ma G, Mbanya J, McGarvey S, Mohan V, Onat A, Pilav A, Ramachandran A, Romdhane H, Paciorek C, Bennett J, Ezzati M, Abdeen Z, Abdul Kadir K, Abu-Rmeileh N, Acosta-Cazares B, Adams R, Aekplakorn W, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Al-Othman A, Alkerwi A, Amouyel P, Amuzu A, Andersen L, Anderssen S, Anjana R, Aounallah-Skhiri H, Aris T, Arlappa N, Arveiler D, Assah F, Avdicová M, Azizi F, Balakrishna N, Bandosz P, Barbagallo C, Barceló A, Batieha A, Baur L, Romdhane H, Benet M, Bernabe-Ortiz A, Bharadwaj S, Bhargava S, Bi Y, Bjerregaard P, Bjertness E, Bjertness M, Björkelund C, Blokstra A, Bo S, Boehm B, Boissonnet C, Bovet P, Brajkovich I, Breckenkamp J, Brenner H, Brewster L, Brian G, Bruno G, Bugge A, Cabrera de León A, Can G, Cândido A, Capuano V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Castetbon K, Chamukuttan S, Chaturvedi N, Chen C, Chen F, Chen S, Cheng C, Chetrit A, Chiou S, Cho Y, Chudek J, Cifkova R, Claessens F, Concin H, Cooper C, Cooper R, Costanzo S, Cottel D, Cowell C, Crujeiras A, D'Arrigo G, Dallongeville J, Dankner R, Dauchet L, de Gaetano G, De Henauw S, Deepa M, Dehghan A, Deschamps V, Dhana K, Di Castelnuovo A, Djalalinia S, Doua K, Drygas W, Du Y, Dzerve V, Egbagbe E, Eggertsen R, El Ati J, Elosua R, Erasmus R, Erem C, Ergor G, Eriksen L, Escobedo-de la Peña J, Fall C, Farzadfar F, Felix-Redondo F, Ferguson T, Fernández-Bergés D, Ferrari M, Ferreccio C, Feskens E, Finn J, Föger B, Foo L, Forslund A, Fouad H, Francis D, Franco Mdo C, Franco O, Frontera G, Furusawa T, Gaciong Z, Garnett S, Gaspoz J, Gasull M, Gates L, Geleijnse J, Ghasemian A, Ghimire A, Giampaoli S, Gianfagna F, Giovannelli J, Giwercman A, Gross M, González Rivas J, Gorbea M, Gottrand F, Grafnetter D, Grodzicki T, Grøntved A, Gruden G, Gu D, Guan O, Guerrero R, Guessous I, Guimaraes A, Gutierrez L, Hambleton I, Hardy R, Hari Kumar R, Hata J, He J, Heidemann C, Herrala S, Hihtaniemi I, Ho S, Ho S, Hofman A, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Htike M, Hu Y, Hussieni A, Huybrechts I, Hwalla N, Iacoviello L, Iannone A, Ibrahim M, Ikeda N, Ikram M, Irazola V, Islam M, Iwasaki M, Jacobs J, Jafar T, Jamil K, Jasienska G, Jiang C, Jonas J, Joshi P, Kafatos A, Kalter-Leibovici O, Kasaeian A, Katz J, Kaur P, Kavousi M, Keinänen-Kiukaanniemi S, Kelishadi R, Kengne A, Kersting M, Khader Y, Khalili D, Khang Y, Kiechl S, Kim J, Kolsteren P, Korrovits P, Kratzer W, Kromhout D, Kujala U, Kula K, Kyobutungi C, Laatikainen T, Lachat C, Laid Y, Lam T, Landrove O, Lanska V, Lappas G, Laxmaiah A, Leclercq C, Lee J, Lee J, Lehtimäki T, Lekhraj R, León-Muñoz L, Li Y, Lim W, Lima-Costa M, Lin H, Lin X, Lissner L, Lorbeer R, Lozano J, Luksiene D, Lundqvist A, Lytsy P, Ma G, Machado-Coelho G, Machi S, Maggi S, Magliano D, Makdisse M, Mallikharjuna Rao K, Manios Y, Manzato E, Margozzini P, Marques-Vidal P, Martorell R, Masoodi S, Mathiesen E, Matsha T, Mbanya J, McFarlane S, McGarvey S, McLachlan S, McNulty B, Mediene-Benchekor S, Meirhaeghe A, Menezes A, Merat S, Meshram I, Mi J, Miquel J, Miranda J, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Mohd Yusoff M, Møller N, Molnár D, Mondo C, Morejon A, Moreno L, Morgan K, Moschonis G, Mossakowska M, Mostafa A, Mota J, Motta J, Mu T, Muiesan M, Müller-Nurasyid M, Mursu J, Nagel G, NámeÅ¡ná J, Nang E, NangThetia V, Navarrete-Muñoz E, Ndiaye N, Nenko I, Nervi F, Nguyen N, Nguyen Q, Nieto-MartÃnez R, Ning G, Ninomiya T, Noale M, Noto D, Nsour M, Ochoa-Avilés A, Oh K, Onat A, Ordunez P, Osmond C, Otero J, Owusu-Dabo E, Pahomova E, Palmieri L, Panda-Jonas S, Panza F, Parsaeian M, Peixoto S, Pelletier C, Peltonen M, Peters A, Peykari N, Pham S, Pilav A, Pitakaka F, Piwonska A, Piwonski J, Plans-Rubió P, Porta M, Portegies M, Poustchi H, Pradeepa R, Price J, Punab M, Qasrawi R, Qorbani M, Radisauskas R, Rahman M, Raitakari O, Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rathmann W, Redon J, Reganit P, Rigo F, Robinson S, Robitaille C, RodrÃguez-Artalejo F, Rodriguez-Perez Mdel C, RodrÃguez-Villamizar L, Rojas-Martinez R, Ronkainen K, Rosengren A, Rubinstein A, Rui O, Ruiz-Betancourt B, Russo Horimoto R, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Sakarya S, Salanave B, Salonen J, Salvetti M, Sánchez-Abanto J, Santos D, dos Santos R, Santos R, Saramies J, Sardinha L, Sarrafzadegan N, Saum K, Scazufca M, Schargrodsky H, Scheidt-Nave C, Sein A, Sharma S, Shaw J, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai A, Simon M, Simons J, Simons L, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Snijder M, So H, Sobngwi E, Söderberg S, Solfrizzi V, Sonestedt E, Soumare A, Staessen J, Stathopoulou M, Steene-Johannessen J, Stehle P, Stein A, Stessman J, Stöckl D, Stokwiszewski J, Stronks K, Strufaldi M, Sun C, Sundström J, Sung Y, Suriyawongpaisal P, Sy R, Tai E, Tamosiunas A, Tang L, Tarawneh M, Tarqui-Mamani C, Taylor A, Theobald H, Thijs L, Thuesen B, Tolonen H, Tolstrup J, Topbas M, Torrent M, Traissac P, Trinh O, Tulloch-Reid M, Tuomainen T, Turley M, Tzourio C, Ueda P, Ukoli F, Ulmer H, Uusitalo H, Valdivia G, Valvi D, van Rossem L, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren W, Verstraeten R, Viet L, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade A, Wagner A, Walton J, Wan Mohamud W, Wang F, Wang M, Wang Q, Wang Y, Wannamethee S, Weerasekera D, Whincup P, Widhalm K, Wiecek A, Wijga A, Wilks R, Willeit J, Wilsgaard T, Wojtyniak B, Wong T, Woo J, Woodward M, Wu F, Wu S, Xu H, Yan W, Yang X, Ye X, Yoshihara A, Younger-Coleman N, Zambon S, Zargar A, Zdrojewski T, Zhao W, Zheng Y, Zuñiga Cisneros J. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. The Lancet 2016, 387: 1513-1530. PMID: 27061677, PMCID: PMC5081106, DOI: 10.1016/s0140-6736(16)00618-8.Peer-Reviewed Original ResearchConceptsPopulation-based studyDiabetes prevalenceAdult prevalenceNumber of adultsOral hypoglycaemic drugsPrevalence of diabetesUse of insulinBurden of diabetesHigh national prevalenceNon-communicable diseasesTerms of prevalenceGlobal targetsHistory of diagnosisHypoglycaemic drugsCrude prevalenceMiddle-income countriesPooled analysisPlasma glucoseNational prevalenceHigh-income countriesDiabetes targetsDiabetesAdult womenPrevalenceWomen
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