2025
Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognition
2024
Healthy Lifestyle and the Likelihood of Becoming a Centenarian
Li Y, Wang K, Jigeer G, Jensen G, Tucker K, Lv Y, Shi X, Gao X. Healthy Lifestyle and the Likelihood of Becoming a Centenarian. JAMA Network Open 2024, 7: e2417931. PMID: 38900423, PMCID: PMC11190803, DOI: 10.1001/jamanetworkopen.2024.17931.Peer-Reviewed Original ResearchConceptsHealthy lifestyleCase-control studyLifestyle factorsOlder adultsChinese Longitudinal Healthy Longevity SurveySelf-reported chronic conditionsHealthy lifestyle scoreImprove lifestyle behaviorsChinese older adultsAssociated with life expectancyProspective nested case-control studyNested case-control studyLifestyle scoreLifestyle behaviorsLongevity SurveyOlder age groupsHealth outcomesChronic conditionsSociodemographic characteristicsCommunity-basedMental wellnessYear of entryMain OutcomesOdds ratioMiddle-aged[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].
Zhong W, Wang X, Song W, Li C, Chen H, Chen Z, Lyu Y, Li Z, Shi X, Mao C. [Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China]. Chinese Journal Of Epidemiology 2024, 45: 41-47. PMID: 38228523, DOI: 10.3760/cma.j.cn112338-20231027-00254.Peer-Reviewed Original ResearchConceptsCognitive frailtyCox proportional hazards regression modelsProportional hazards regression modelsPhysical activityHazards regression modelsHealthy lifestyleLevels of physical activityChinese Longitudinal Healthy Longevity SurveyElderly populationRegular physical activityDietary diversityLevel of dietary diversityAssociation of lifestyleAPOE geneImpact of lifestyleRegression modelsAdditive interactionAPOE e4 alleleLifestyle scoreCombined lifestyleLongevity SurveyPhysical frailtyStudy participantsElderly personsLifestyle
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