2025
Association of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotide
2024
[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].
Zhong W, Wang X, Song W, Li C, Chen H, Chen Z, Lyu Y, Li Z, Shi X, Mao C. [Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China]. Chinese Journal Of Epidemiology 2024, 45: 41-47. PMID: 38228523, DOI: 10.3760/cma.j.cn112338-20231027-00254.Peer-Reviewed Original ResearchConceptsCognitive frailtyCox proportional hazards regression modelsProportional hazards regression modelsPhysical activityHazards regression modelsHealthy lifestyleLevels of physical activityChinese Longitudinal Healthy Longevity SurveyElderly populationRegular physical activityDietary diversityLevel of dietary diversityAssociation of lifestyleAPOE geneImpact of lifestyleRegression modelsAdditive interactionAPOE e4 alleleLifestyle scoreCombined lifestyleLongevity SurveyPhysical frailtyStudy participantsElderly personsLifestyle
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