2025
mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae
Dolan B, Correa Gaviria T, Dong Y, Cresswell P, Dimopoulos G, Chuang Y, Fikrig E. mosGILT antibodies interfere with Plasmodium sporogony in Anopheles gambiae. Nature Communications 2025, 16: 592. PMID: 39799117, PMCID: PMC11724845, DOI: 10.1038/s41467-025-55902-1.Peer-Reviewed Original ResearchConceptsCausative agent of malariaTransmission-blocking vaccinesMurine infection modelPlasmodium life cycleAgent of malariaGamma-interferon-inducible lysosomal thiol reductaseP. falciparumInfection modelAnopheles gambiaeMosquito midgutPlasmodiumLysosomal thiol reductaseCausative agentAntibodiesOocyst stageInfection prevalenceThiol reductaseMalariaGambiaInfectionMosquitoesPrevalenceVaccine
2014
Innexin AGAP001476 Is Critical for Mediating Anti-Plasmodium Responses in Anopheles Mosquitoes
Li MW, Wang J, Zhao YO, Fikrig E. Innexin AGAP001476 Is Critical for Mediating Anti-Plasmodium Responses in Anopheles Mosquitoes. Journal Of Biological Chemistry 2014, 289: 24885-24897. PMID: 25035430, PMCID: PMC4155657, DOI: 10.1074/jbc.m114.554519.Peer-Reviewed Original ResearchConceptsAnti-Plasmodium responseToll pathwayInnate immune responseGap junction proteinIMD pathwaySignal transductionExtracellular communicationSimultaneous knockdownAnopheles gambiaeImmune responseMidgut epitheliumInhibitor studiesKnockdownPlasmodium falciparum infectionCactusBlood mealGap junctionsVitellogenin levelsOocyst numbersAnopheles mosquitoesJunction proteinsCritical rolePathwayMRNA levelsMosquitoes
2012
Enhanced Survival of Plasmodium-Infected Mosquitoes during Starvation
Zhao YO, Kurscheid S, Zhang Y, Liu L, Zhang L, Loeliger K, Fikrig E. Enhanced Survival of Plasmodium-Infected Mosquitoes during Starvation. PLOS ONE 2012, 7: e40556. PMID: 22808193, PMCID: PMC3393683, DOI: 10.1371/journal.pone.0040556.Peer-Reviewed Original ResearchConceptsSurvival advantageInsulin-like signalingAbility of mosquitoesInsulin-like peptidesInfection altersUninfected mosquitoesOocyst developmentPlasmodium developmentEnhanced expressionInsect vectorsPeriods of starvationFitness costsEnhanced survivalVertebrate hostsMicroarray analysisCarbohydrate catabolismCause malariaPlasmodiumStarvationMosquitoes
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