Featured Publications
Longitudinal Trajectories of Multiple Nicotine Product Use Among Youths in the Population Assessment of Tobacco and Health Study
Simon P, Jiang Y, Buta E, Sartor CE, Krishnan-Sarin S, Gueorguieva R. Longitudinal Trajectories of Multiple Nicotine Product Use Among Youths in the Population Assessment of Tobacco and Health Study. JAMA Network Open 2022, 5: e223549. PMID: 35319763, PMCID: PMC8943628, DOI: 10.1001/jamanetworkopen.2022.3549.Peer-Reviewed Original ResearchConceptsNicotine product useCigar useTobacco usersTobacco useHealth StudyCigarette useProduct useWave 1Significant public health concernLongitudinal trajectoriesPublic health concernNon-Hispanic whitesTobacco product useLogistic regression modelsTobacco use behaviorsComplex survey designMultinomial logistic regression modelsDays of useSocioecological factorsMAIN OUTCOMESmokeless tobaccoLower oddsNicotine productsLatent class growth analysisSociodemographic factors
2024
A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol
Bold K, Sharma A, Haeny A, Gueorguieva R, Buta E, Baldassarri S, Lempert L, Krishnan-Sarin S, O’Malley S. A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol. BMC Psychiatry 2024, 24: 201. PMID: 38475757, PMCID: PMC10935798, DOI: 10.1186/s12888-024-05619-0.Peer-Reviewed Original ResearchConceptsSmoking menthol cigarettesE-cigarettesCigarette useReduce tobacco-related health disparitiesTobacco-related health disparitiesMenthol cigarettesRates of menthol cigarette useTobacco use statusMenthol cigarette useRandomized controlled trialsPublic health problemHealth disparitiesTobacco policiesFlavored e-cigarettesSmoke-freeMenthol flavorsMenthol policiesBlack adultsQuit smokingNon-Black participantsSmoking behaviorFollow-up visitHealth problemsSecondary outcomesE-cigarette products
2023
A Network Analysis of Cigarette Craving.
Aslan M, Sala M, Gueorguieva R, Garrison K. A Network Analysis of Cigarette Craving. Nicotine & Tobacco Research 2023, 25: 1155-1163. PMID: 36757093, PMCID: PMC10202645, DOI: 10.1093/ntr/ntad021.Peer-Reviewed Original ResearchThreshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleNicotineSmoking CessationTobaccoTobacco ProductsTobacco Use DisorderYoung AdultConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adultsThe first nicotine product tried is associated with current multiple nicotine product use and nicotine dependence among a nationally representative sample of U.S. youths
Simon P, Buta E, Jackson A, Camenga D, Kong G, Morean M, Bold K, Davis D, Krishnan-Sarin S, Gueorguieva R. The first nicotine product tried is associated with current multiple nicotine product use and nicotine dependence among a nationally representative sample of U.S. youths. Preventive Medicine 2023, 169: 107437. PMID: 36731754, PMCID: PMC10507373, DOI: 10.1016/j.ypmed.2023.107437.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildElectronic Nicotine Delivery SystemsHumansNicotineTobacco ProductsTobacco UseTobacco Use DisorderUnited StatesConceptsNicotine product useSymptoms of dependenceNicotine dependenceMultiple product useSmokeless tobaccoNicotine productsProduct useSeparate multinomial logistic regression modelsHealth Study Waves 1Wave 1Smokeless tobacco usersHigher nicotine dependence scoresNicotine dependence scoresDemographic factorsLogistic regression modelsMultinomial logistic regression modelsMultivariable modelTobacco usersHigh riskDependence scoresSymptomsGreater likelihoodUse statusWave 4Regression models
2022
Models for Zero-Inflated and Overdispersed Correlated Count Data: An Application to Cigarette Use
Pittman B, Buta E, Garrison K, Gueorguieva R. Models for Zero-Inflated and Overdispersed Correlated Count Data: An Application to Cigarette Use. Nicotine & Tobacco Research 2022, 25: 996-1003. PMID: 36318799, PMCID: PMC10077942, DOI: 10.1093/ntr/ntac253.Peer-Reviewed Original ResearchMeSH KeywordsHumansLongitudinal StudiesModels, StatisticalNicotinePoisson DistributionTobaccoTobacco ProductsConceptsCorrelated count dataCount outcomesCount dataSubject-specific interpretationZero-InflatedIncorrect statistical inferenceStatistical inferenceCorrelated countsPoisson distributionOverdispersionModel assumptionsPoisson modelRandom effectsHurdle Poisson modelProper modelNegative binomial modelBinomial modelSuch dataAppropriate modelBest fitLarge varianceTobacco researchSuch outcomesModel fitTraining appExamining the potential role of e-cigarettes to reduce health disparities associated with menthol cigarette use: Characterizing e-cigarette use, flavors, and reasons for use among US adults smoking menthol cigarettes
Bold KW, Buta E, Simon P, Gueorguieva R, Jackson A, Suttiratana SC, Krishnan-Sarin S, O'Malley SS. Examining the potential role of e-cigarettes to reduce health disparities associated with menthol cigarette use: Characterizing e-cigarette use, flavors, and reasons for use among US adults smoking menthol cigarettes. Drug And Alcohol Dependence 2022, 236: 109475. PMID: 35594642, PMCID: PMC9248755, DOI: 10.1016/j.drugalcdep.2022.109475.Peer-Reviewed Original ResearchMeSH KeywordsAgedElectronic Nicotine Delivery SystemsFlavoring AgentsHumansMentholTobaccoTobacco ProductsVapingNovel Nicotine Concentration Labels Improve Adolescents’ and Young Adults’ Understanding of the Nicotine Strength of Electronic Nicotine Delivery System Products
Morean ME, Wackowski OA, Eissenberg T, Delnevo CD, Krishnan-Sarin S, Gueorguieva R. Novel Nicotine Concentration Labels Improve Adolescents’ and Young Adults’ Understanding of the Nicotine Strength of Electronic Nicotine Delivery System Products. Nicotine & Tobacco Research 2022, 24: 1110-1119. PMID: 35137219, PMCID: PMC9199936, DOI: 10.1093/ntr/ntac024.Peer-Reviewed Original Research
2021
The Effects of Inhaled Flavors on Intravenous Nicotine
MacLean RR, Gueorguieva R, DeVito EE, Peltier MR, Parida S, Sofuoglu M. The Effects of Inhaled Flavors on Intravenous Nicotine. Experimental And Clinical Psychopharmacology 2021, 29: 615-624. PMID: 32463279, PMCID: PMC7704548, DOI: 10.1037/pha0000394.Peer-Reviewed Original ResearchMeSH KeywordsElectronic Nicotine Delivery SystemsFlavoring AgentsHumansMentholNicotineSmokersTobacco ProductsYoung AdultConceptsCigarette smokersIntravenous nicotineE-cigarettesYoung adult cigarette smokersSubject cross-over designAdult cigarette smokersMain outcome measuresPeak heart rateHigher following administrationCross-over designAcute rewarding effectsPresent studyFollowing administrationAcute effectsOutcome measuresHeart rateRewarding effectsTobacco cigarettesSmoking urgesRewarding propertiesNicotineAddictive effectsHigher cravingMenthol flavorsThousands of flavorsAssociation of Vaping and Respiratory Health among Youth in the Population Assessment of Tobacco and Health (PATH) Study Wave 3
Cherian C, Buta E, Simon P, Gueorguieva R, Krishnan-Sarin S. Association of Vaping and Respiratory Health among Youth in the Population Assessment of Tobacco and Health (PATH) Study Wave 3. International Journal Of Environmental Research And Public Health 2021, 18: 8208. PMID: 34360499, PMCID: PMC8346152, DOI: 10.3390/ijerph18158208.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCross-Sectional StudiesElectronic Nicotine Delivery SystemsHumansTobaccoTobacco ProductsUnited StatesVapingConceptsDry coughRespiratory manifestationsHigher oddsExercise-induced wheezingPulmonary clinical manifestationsSerious pulmonary complicationsNicotine product useLogistic regression modelsPulmonary complicationsAsthma diagnosisInhaler useWave 3Clinical manifestationsRespiratory healthEarly recognitionHealth SurveyTobacco useClinical effortsLifetime numberPrevention effortsPast yearPopulation AssessmentWheezingProduct useCoughInfluence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users
Jackson A, Green B, Erythropel HC, Kong G, Cavallo DA, Eid T, Gueorguieva R, Buta E, O’Malley S, Krishnan-Sarin S. Influence of Menthol and Green Apple E-Liquids Containing Different Nicotine Concentrations Among Youth E-Cigarette Users. Experimental And Clinical Psychopharmacology 2021, 29: 355-365. PMID: 32297782, PMCID: PMC7572568, DOI: 10.1037/pha0000368.Peer-Reviewed Original ResearchAcute effects of inhaled menthol on cognitive effects of intravenous nicotine among young adult cigarette smokers
Jao NC, Gueorguieva R, Hitsman B, Sofuoglu M. Acute effects of inhaled menthol on cognitive effects of intravenous nicotine among young adult cigarette smokers. Addictive Behaviors 2021, 122: 107022. PMID: 34174551, PMCID: PMC8328965, DOI: 10.1016/j.addbeh.2021.107022.Peer-Reviewed Original ResearchConceptsContinuous performance taskMathematical processing taskCognitive effectsIntravenous nicotineCognitive task performanceYoung adult cigarette smokersType preferencesYoung adult smokersStroop taskCognitive tasksCognitive functioningCognitive performanceTask performancePerformance taskStroopAdult cigarette smokersProcessing tasksNicotine dosesNicotine dependenceTaskInteractive effectsParticipantsMixed effects modelsHigh nicotineSessions
2020
Trends in various e-cigarette devices used by high school adolescents from 2017-2019
Bold KW, Kong G, Morean M, Gueorguieva R, Camenga DR, Simon P, Davis DR, Jackson A, Krishnan-Sarin S. Trends in various e-cigarette devices used by high school adolescents from 2017-2019. Drug And Alcohol Dependence 2020, 219: 108497. PMID: 33421797, PMCID: PMC7861878, DOI: 10.1016/j.drugalcdep.2020.108497.Peer-Reviewed Original ResearchSmoking history and the association between alcohol and e‐cigarette use: authors’ reply
Roberts W, Verplaetse T, Peltier MKR, Moore KE, Gueorguieva R, McKee SA. Smoking history and the association between alcohol and e‐cigarette use: authors’ reply. Addiction 2020, 116: 971-972. PMID: 33220148, PMCID: PMC8856131, DOI: 10.1111/add.15347.Peer-Reviewed Original ResearchProspective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health
Roberts W, Verplaetse T, Peltier MKR, Moore KE, Gueorguieva R, McKee SA. Prospective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health. Addiction 2020, 115: 1571-1579. PMID: 31977106, PMCID: PMC7340560, DOI: 10.1111/add.14980.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesHazardous alcohol useE-cigarette useE-cigarettesCigarette useAlcohol useUse outcomesExposure groupCigarette usersTotal drinksSocio-demographic risk factorsUnited States adult populationWave 1Non-institutionalized adultsStates adult populationHarmful alcohol consumptionNon-daily useE-cigarette usersPoorer alcohol use outcomesSocio-demographic characteristicsRisk factorsHealth SurveyHigher oddsTobacco cigarettesAlcohol abuseTransitions across tobacco use profiles among adolescents: results from the Population Assessment of Tobacco and Health (PATH) study waves 1 and 2
Simon P, Buta E, Gueorguieva R, Kong G, Morean ME, Camenga D, Bold KW, Krishnan‐Sarin S. Transitions across tobacco use profiles among adolescents: results from the Population Assessment of Tobacco and Health (PATH) study waves 1 and 2. Addiction 2020, 115: 740-747. PMID: 31618491, PMCID: PMC7361287, DOI: 10.1111/add.14828.Peer-Reviewed Original ResearchConceptsUse of cigarettesE-cigarettesHealth Study Waves 1Wave 1US youthProbability of progressionUsers of cigarettesNon-institutionalized populationTobacco use statusTobacco use profilesSocio-demographic predictorsRate of useCurrent useProspective surveyMore tobacco productsLatent transition analysisSmokeless tobaccoNicotine productsHealth StudyUS civilianParental education levelTobacco productsCigarettesPopulation AssessmentUse status
2018
Impact of E-cigarettes on Smoking and Related Outcomes in Veteran Smokers With Psychiatric Comorbidity
Valentine GW, Hefner K, Jatlow PI, Rosenheck RA, Gueorguieva R, Sofuoglu M. Impact of E-cigarettes on Smoking and Related Outcomes in Veteran Smokers With Psychiatric Comorbidity. Journal Of Dual Diagnosis 2018, 14: 2-13. PMID: 29083287, PMCID: PMC7131866, DOI: 10.1080/15504263.2017.1384877.Peer-Reviewed Original ResearchConceptsE-cigarette usePsychiatric comorbidityCombustible cigarette useE-cigarettesVeteran smokersQuit ratesNicotine dependenceCigarette useVeterans Affairs Health Care SystemAlveolar carbon monoxide levelsOpen-label studySerious adverse eventsSmoking-related deathsFrequent e-cigarette useMain outcome measuresNumber of cigarettesOne-month followEvidence-based treatmentsTobacco-related harmSubstance use disordersGeneral U.S. populationLower quit ratesNicotine delivery systemsCombustible tobacco useHealth care system
2017
Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes
Krishnan-Sarin S, Green BG, Kong G, Cavallo DA, Jatlow P, Gueorguieva R, Buta E, O’Malley S. Studying the interactive effects of menthol and nicotine among youth: An examination using e-cigarettes. Drug And Alcohol Dependence 2017, 180: 193-199. PMID: 28915478, PMCID: PMC5659733, DOI: 10.1016/j.drugalcdep.2017.07.044.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentElectronic Nicotine Delivery SystemsGlucuronatesHumansMentholNicotineSubstance Withdrawal SyndromeTasteTobacco ProductsConceptsAd lib useE-cigarettesE-cigarette usersStimulant effectsNicotine concentrationsNicotine-containing e-cigarettesNicotine withdrawal symptomsMenthol concentrationRandom counterbalanced orderPositive rewarding effectsNicotine exposureNicotine withdrawalWithdrawal symptomsRewarding effectsMenthol glucuronideHigh menthol concentrationLow dosesNicotine levelsTobacco productsNicotineCounterbalanced order