Featured Publications
Illusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original ResearchTemporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response
Gueorguieva R, Wu R, Krystal JH, Donovan D, O'Malley SS. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addictive Behaviors 2013, 38: 2119-2127. PMID: 23435273, PMCID: PMC3595348, DOI: 10.1016/j.addbeh.2013.01.024.Peer-Reviewed Original ResearchConceptsPercent heavy drinking daysAdherence trajectoriesExcellent adherersPercent days abstinentPatient characteristicsMedication adherenceTreatment outcomesMedication adherence trajectoriesPatterns of treatmentHeavy drinking daysPatterns of adherenceExcellent medication adherenceLack of benefitTrajectories of adherenceIntervention main effectsActive medicationAdverse eventsPharmacologic treatmentHigher percent days abstinentTreatment adherenceTreatment modalitiesWorse outcomesTreatment responseDays abstinentDrinking daysCross-trial prediction of treatment outcome in depression: a machine learning approach
Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. The Lancet Psychiatry 2016, 3: 243-250. PMID: 26803397, DOI: 10.1016/s2215-0366(15)00471-x.Peer-Reviewed Original ResearchConceptsTreatment outcomesTreatment groupsEscitalopram treatment groupSpecific antidepressantsPatient-reported dataSequenced Treatment AlternativesClinical trial dataIndependent clinical trialsClinical remissionSymptomatic remissionClinical trialsTreatment efficacyPatientsProspective identificationTreatment alternativesTrial dataDepressionRemissionAntidepressantsOutcomesGroupLevel 1CitalopramCohortClinicians
2024
The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2021
Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder
Boswell RG, Gueorguieva R, Grilo CM. Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder. Psychological Medicine 2021, 53: 2789-2797. PMID: 34812713, PMCID: PMC9124732, DOI: 10.1017/s003329172100475x.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyCognitive behavioral therapyTreatment outcomesDepression scoresPharmacological treatmentRandomized placebo-controlled clinical trialPlacebo-controlled clinical trialEfficacy of CBTBinge-eating disorderBaseline impulsivityAssociation of rapidClinical trialsTreatment groupsOverall changeDisorder psychopathologyMixed effects modelsOutcomesTreatmentBMIPatientsMeasures of impulsivityScoresPsychopathologyGeneral outcomeImpulsivityExamining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder
Grilo CM, Gueorguieva R, Pittman B. Examining depression scores as predictors and moderators of treatment outcomes in patients with binge‐eating disorder. International Journal Of Eating Disorders 2021, 54: 1555-1559. PMID: 34137474, DOI: 10.1002/eat.23569.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBinge-eating disorderEvidence-based psychological interventionsDepression scoresEating Disorder PsychopathologyBinge-eating frequencyPredictors/moderatorsModerators of responseElevated depression scoresPsychological interventionsBWL interventionModeratorTreatment outcomesBaseline depression scoresLong-term outcomesBWLModerate outcomeFindings reinforceDepressionScoresDisordersInterventionPsychopathologyEarly changesPatientsRandomized Controlled Trial of Treatments for Loss‐of‐Control Eating Following Bariatric Surgery
Grilo CM, Ivezaj V, Duffy AJ, Gueorguieva R. Randomized Controlled Trial of Treatments for Loss‐of‐Control Eating Following Bariatric Surgery. Obesity 2021, 29: 689-697. PMID: 33694287, PMCID: PMC7995173, DOI: 10.1002/oby.23124.Peer-Reviewed Original ResearchConceptsBariatric surgeryWeight lossAllied health cliniciansBariatric surgery outcomesThree-month treatmentSelf-help treatmentBariatric surgery settingsSignificant differencesControlled TrialsSurgery settingSurgery outcomesTreatment outcomesHealth cliniciansPosttreatment outcomesNon-White participantsControl eatingSurgeryTrialsOutcomesTreatmentPatientsCategorical outcomesWhite participantsAbstinenceHigher proportion
2020
Examining Self-Weighing Behaviors and Associated Features and Treatment Outcomes in Patients with Binge-Eating Disorder and Obesity with and without Food Addiction
Wiedemann AA, Ivezaj V, Gueorguieva R, Potenza MN, Grilo CM. Examining Self-Weighing Behaviors and Associated Features and Treatment Outcomes in Patients with Binge-Eating Disorder and Obesity with and without Food Addiction. Nutrients 2020, 13: 29. PMID: 33374870, PMCID: PMC7823454, DOI: 10.3390/nu13010029.Peer-Reviewed Original ResearchConceptsBinge-eating disorderFood addictionFrequency of weighingShape/weightRelated perceptionsEating Disorder ExaminationBinge Eating DisorderBehavioral weight loss treatmentWeight loss treatmentDisorder ExaminationLess acceptanceFrequent weighingPoor treatment outcomesTreatment outcomesNegative reactionsBWL treatmentParticipantsLoss treatmentMixed effects modelsPerceptionFA statusAddictionAssociated featuresGreater likelihoodIndividuals
2019
Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials. International Journal Of Eating Disorders 2019, 53: 20-30. PMID: 31497876, PMCID: PMC6983351, DOI: 10.1002/eat.23167.Peer-Reviewed Original ResearchConceptsBinge-eating disorderEating-disorder psychopathologyCognitive behavioral therapySelf-report measuresModerators of outcomeTreatment outcomesBehavioral weight lossStatistical Manual-Fourth EditionSignificant moderatorWeight lossControl conditionModeratorCourse of treatmentBetter treatment outcomesGreater weight lossMain effectStructured interviewsTreatment settingsPsychopathologyMultimodal treatmentPatient groupRCT studiesMedical CenterBed treatmentParticipantsExamining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials. Journal Of Consulting And Clinical Psychology 2019, 87: 530-540. PMID: 31008634, PMCID: PMC6589831, DOI: 10.1037/ccp0000404.Peer-Reviewed Original ResearchConceptsBinge-eating disorderWhite participantsCognitive behavioral therapySelf-report measuresTreatment outcomesBinge-eating remissionModerate treatment outcomeBinge Eating DisorderBinge-eating episodesMain effectBlack participantsWeight lossBehavioral weight lossEvidence-based treatmentsLower depressionTreatment researchRandomized Controlled TrialsBetter treatment outcomesControl conditionParticipantsControlled TrialsMultimodal treatmentPercent weight lossPatient groupModerator
2015
Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE.
Gueorguieva R, Wu R, Fucito LM, O'Malley SS. Predictors of Abstinence From Heavy Drinking During Follow-Up in COMBINE. Journal Of Studies On Alcohol And Drugs 2015, 76: 935-41. PMID: 26562602, PMCID: PMC4712662, DOI: 10.15288/jsad.2015.76.935.Peer-Reviewed Original ResearchConceptsLong-term outcomesBetter long-term outcomesBetter clinical outcomesDrinking outcomesHeavy drinking daysLogistic regression analysisStrongest predictorLogistic regression modelsPredictors of abstinenceFair classification accuracyPatient characteristicsClinical outcomesTerm outcomesCombined PharmacotherapiesClinical trialsBaseline predictorsTreatment outcomesTreatment phaseOptimizing outcomesDrinking daysBetter outcomesAlcohol Dependence (COMBINE) StudyBehavioral interventionsHeavy drinkingAlternative interventions
2012
Predictive significance of the overvaluation of shape/weight in obese patients with binge eating disorder: findings from a randomized controlled trial with 12-month follow-up
Grilo CM, White MA, Gueorguieva R, Wilson GT, Masheb RM. Predictive significance of the overvaluation of shape/weight in obese patients with binge eating disorder: findings from a randomized controlled trial with 12-month follow-up. Psychological Medicine 2012, 43: 1335-1344. PMID: 22967857, PMCID: PMC3666331, DOI: 10.1017/s0033291712002097.Peer-Reviewed Original ResearchConceptsShape/weightCognitive behavioral therapyBehavioral weight lossPoor psychological functioningEating-related psychopathologySelf-esteem levelPsychological functioningDisorder psychopathologyOvervaluation groupBehavioral therapyPsychological distressGroup treatmentFrequent bingeCore featuresSemi-structured interviewsBingeGroup differencesObese patientsTreatment outcomesPredictive significanceLong-term treatment outcomesDiagnostic specifierPsychopathologyGreater levelsNegative prognostic significanceCigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
Fucito LM, Park A, Gulliver SB, Mattson ME, Gueorguieva RV, O'Malley SS. Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence. Biological Psychiatry 2012, 72: 832-838. PMID: 22541040, PMCID: PMC3410039, DOI: 10.1016/j.biopsych.2012.03.023.Peer-Reviewed Original ResearchConceptsCigarette smokingAlcohol dependenceBehavioral interventionsAlcohol-dependent smokersCombination of medicationsBaseline demographic differencesPoor treatment outcomesPoor treatment responseDrinking outcomesBetter drinking outcomesSevere alcohol dependenceAlcohol-dependent individualsCigarette intakeAlcohol use outcomesMedical managementPharmacological treatmentTreatment outcomesTreatment responseSmokingSmokersCOMBINE StudyAlcoholism typologyDrinking-related variablesTreatment assignmentNonsmokers