Featured Publications
Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis
Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet Psychiatry 2017, 4: 230-237. PMID: 28189575, PMCID: PMC5340978, DOI: 10.1016/s2215-0366(17)30038-x.Peer-Reviewed Original ResearchConceptsActive medicationActive treatmentClinical trialsDepression severityHamilton Depression Rating Scale scoresDepression Rating Scale scoresClinical Global Impression scoresIndividual patient-level dataDouble-blind treatmentPlacebo-controlled trialPatterns of relapseGlobal Impression scoresIndividual patient dataPrevention of relapseTrajectory class membershipTreatment of depressionMajor depressive disorderRating Scale scoresPatient-level dataPost-traumatic stress disorderTreatment discontinuationAntidepressant treatmentClinical responseAlcohol Research CenterAntidepressant medication
2013
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression
Hantsoo L, Ward-O’Brien D, Czarkowski KA, Gueorguieva R, Price LH, Epperson CN. A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. Psychopharmacology 2013, 231: 939-948. PMID: 24173623, PMCID: PMC3945214, DOI: 10.1007/s00213-013-3316-1.Peer-Reviewed Original ResearchConceptsDSM-IV criteriaDouble-blind placebo-controlled trialSelective serotonin reuptake inhibitor sertralineSerotonin reuptake inhibitor sertralineClinical Global Impression scoresHamilton Depression Rating ScaleRating ScaleStrict DSM-IV criteriaDouble-blind trialPlacebo-controlled studyPlacebo-controlled trialHamilton Anxiety Rating ScaleMonths of deliverySubset of womenPrimary outcome variableWeeks of childbirthDepression Rating ScaleGlobal Impression scoresGreater response rateMajor depressive disorderOnset of depressionAnxiety Rating ScaleSignificant groupSertraline 50Remission rate