Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis
D'Souza DC, Ranganathan M, Braley G, Gueorguieva R, Zimolo Z, Cooper T, Perry E, Krystal J. Blunted Psychotomimetic and Amnestic Effects of Δ-9-Tetrahydrocannabinol in Frequent Users of Cannabis. Neuropsychopharmacology 2008, 33: 2505-2516. PMID: 18185500, PMCID: PMC3799954, DOI: 10.1038/sj.npp.1301643.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmnesiaAttentionBrainDose-Response Relationship, DrugDouble-Blind MethodDronabinolDrug Administration ScheduleDrug ToleranceFemaleHallucinationsHallucinogensHumansHydrocortisoneMaleMarijuana AbuseMiddle AgedPerceptual DisordersProlactinPsychoses, Substance-InducedTachycardiaYoung AdultConceptsAmnestic effectsPerceptual alterationsDelta-9-TetrahydrocannabinolCannabis useSubjective effectsFrequent usersCannabisEffects of cannabinoidsIllicit substancesPsychotomimetic effectsEuphoric effectsHealthy controlsHealthy individualsMemoryImpairingPsychosisDose-related effectsIndividualsCortisolPsychotomimeticsAttentionPeopleUsersPlacebo-controlled studyEffectCortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia
Gunduz-Bruce H, Szeszko PR, Gueorguieva R, Ashtari M, Robinson DG, Kane JM, Bilder RM. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia Research 2007, 94: 281-287. PMID: 17490857, DOI: 10.1016/j.schres.2007.03.025.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaHippocampal volumeRegional hippocampal volumesCortisol levelsEpisode schizophreniaAnterior hippocampal volumeDiurnal salivary cortisol levelsSalivary cortisol levelsCoronal MR imagesHigher cortisol levelsCushing's syndromeFirst admissionPatient groupHealthy controlsCortisol exposureHealthy adolescentsSignificant associationSchizophreniaVolumetric reductionCortisol measuresLarge-scale studiesGenetic factorsSchizophrenia sampleSyndromeCortisol