2025
Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa
Heinsberg L, Loia M, Tasele S, Faasalele-Savusa K, Carlson J, Anesi S, Desobry K, Yuchongco E, Guevara B, Sesaga A, Iloilo A, Tofaeono V, Bryan K, Tauasosi-Posiulai T, Kershaw E, Conley Y, Weeks D, Hawley N, Muasau-Howard B. Study protocol for the Health Outcomes in Pregnancy and Early Childhood (HOPE) Study: A mother-infant study in American Samoa. PLOS ONE 2025, 20: e0326644. PMID: 40952996, PMCID: PMC12435730, DOI: 10.1371/journal.pone.0326644.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusBody mass indexHealth outcomesBurden of gestational diabetes mellitusLower risk of type 2 diabetesAmerican Samoa Department of HealthAssociated with higher body mass indexLow riskGestational diabetes statusRisk of type 2 diabetesHigher Body Mass IndexCord blood DNA methylationLongitudinal cohort studyDepartment of HealthInfant body sizePacific IslandersPeer-reviewed publicationsType 2 diabetesBlood DNA methylationInstitutional review boardAmerican SamoaPregnant womenInfant growthFollow-upMass index
2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting GlucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher Body Mass IndexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
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