2025
A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women
Erdogan-Yildirim Z, Carlson J, Krishnan M, Zhang J, Lambert-Messerlian G, Naseri T, Viali S, Hawley N, McGarvey S, Weeks D, Minster R. A Genome-Wide Association Study of Anti-Müllerian Hormone (AMH) Levels in Samoan Women. Genes 2025, 16: 793. PMID: 40725450, PMCID: PMC12294779, DOI: 10.3390/genes16070793.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptome-wide association analysisAssociation studiesGenome-wide suggestive lociExpression quantitative trait lociGene-based testsQuantitative trait lociBiologically plausible candidate genesCox mixed-effects modelsWomen of European ancestryAnti-Mullerian hormoneLead variantsSuggestive lociGenetic lociTrait lociAnti-Mullerian hormone levelsCandidate genesReproductive phenotypesSignificant genesAssociation analysisGenetic determinantsEuropean ancestryLociGenesRegulation of ovarian follicle development
2020
Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels
Carlson JC, Weeks DE, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Tuitele J, Deka R, McGarvey ST, Minster RL. Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels. Journal Of Human Genetics 2020, 66: 111-121. PMID: 32759990, PMCID: PMC7785639, DOI: 10.1038/s10038-020-0816-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultApolipoprotein A-IApolipoproteins ECholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLCohort StudiesFastingFemaleGenetic MarkersGenome-Wide Association StudyHumansLipid MetabolismLipidsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociSamoaTriglyceridesConceptsGenome-wide association studiesGenetic architectureAssociation studiesGenome-wide significant associationDifferent association signalsUnique population historyPopulation bottlenecksLipid lociPopulation historyAssociation signalsSuggestive associationRab21Current understandingMGAT1Association of variantsReplication cohortLipidsBiological foundationsVariantsLociLow-density lipoproteinInsightsPopulationLipid levelsHigh-density lipoprotein
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