Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment
Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: Utility of current database and implications for human health risk assessment. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2011, 727: 1-15. PMID: 21352951, DOI: 10.1016/j.mrrev.2011.02.001.Peer-Reviewed Original ResearchMeSH KeywordsDNA RepairDNA-Binding ProteinsGene ExpressionHumansPolymorphism, GeneticRisk AssessmentX-ray Repair Cross Complementing Protein 1ConceptsBase excision repairDNA repairGene expressionRepair functionUpstream regulatory sequencesDNA damaging agentsHomozygous variantToxicodynamic responseXRCC1 levelsRegulatory sequencesBinding sequenceExcision repairDamaging agentsProtein structureBER genesDNA damageAllele frequenciesCurrent databasePolymorphismGenotype effectsArg399Gln variantPhenotypeGenetic polymorphismsXRCC1Environmental agents