2025
The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity.
Betensky D, Smith K, Katz J, Yang C, Hunter D, Collins J, Feldman C, Messier S, Kim J, Selzer F, Paltiel A, Losina E. The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity. Annals Of Internal Medicine 2025 PMID: 40953447, DOI: 10.7326/annals-24-03609.Peer-Reviewed Original ResearchQuality-adjusted life yearsBody mass indexIncremental cost-effectiveness ratioKnee osteoarthritisWestern Ontario and McMaster Universities Osteoarthritis Index pain scorePain reductionBaseline body mass indexQuality-adjusted life year thresholdsHealth benefitsMicrosimulation modelWeight loss strategiesCost-effectiveMean body mass indexUsual careHealth policyCost-effectiveness thresholdOsteoarthritis Policy ModelCost-effectiveness ratioGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsLife yearsBase-case cohortMass indexLoss strategiesMedical costs
2023
Cost‐Effectiveness of Weight‐Loss Interventions Prior to Total Knee Replacement for Patients With Class III Obesity
Kostic AM, Leifer VP, Selzer F, Hunter DJ, Paltiel AD, Chen AF, Robinson MK, Neogi T, Collins JE, Messier SP, Edwards RR, Katz JN, Losina E. Cost‐Effectiveness of Weight‐Loss Interventions Prior to Total Knee Replacement for Patients With Class III Obesity. Arthritis Care & Research 2023, 75: 1752-1763. PMID: 36250415, PMCID: PMC10375659, DOI: 10.1002/acr.25044.Peer-Reviewed Original ResearchConceptsLaparoscopic sleeve gastrectomyClass III obesityIncremental cost-effectiveness ratioTotal knee replacementQuality-adjusted life expectancyWeight loss interventionProbabilistic sensitivity analysesKnee replacementNonsurgical weight loss interventionsLong-term clinical benefitWeight lossKnee osteoarthritis patientsWeight loss strategiesHealth care sector perspectiveOsteoarthritis Policy ModelLifetime medical costsCost-effectiveness ratioWeight loss/Gastric bypassSleeve gastrectomyPrimary outcomeLoss interventionOsteoarthritis patientsClinical benefitHigher complications
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