2012
ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets
Luo Y, Dallaglio K, Chen Y, Robinson WA, Robinson SE, McCarter MD, Wang J, Gonzalez R, Thompson DC, Norris DA, Roop DR, Vasiliou V, Fujita M. ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets. Stem Cells 2012, 30: 2100-2113. PMID: 22887839, PMCID: PMC3448863, DOI: 10.1002/stem.1193.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyAldehyde OxidoreductasesAnimalsApoptosisCell Transformation, NeoplasticDacarbazineDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticGene SilencingHumansIsoenzymesMelanomaMiceMice, Inbred NODMice, SCIDNeoplasm TransplantationNeoplastic Stem CellsResponse ElementsRetinal DehydrogenaseRNA, Small InterferingSkin NeoplasmsTemozolomideTretinoinConceptsCancer stem cellsPositive melanoma cellsMelanoma cellsTherapeutic targetBiomarkers of CSCsHuman melanomaPatient-derived tumor specimensMelanoma cancer stem cellsNOD/SCID miceALDH-negative cellsHigh aldehyde dehydrogenase (ALDH) activityALDH isozymesNonobese diabetic/Potential therapeutic targetDrug-induced cell deathAttractive therapeutic targetNew molecular targetsHuman melanoma cellsStem cellsMelanoma stem cellsAldehyde dehydrogenase activityHuman melanoma stem cellsNSG miceCell cycle arrestImmunodeficiency mice
2005
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Dwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Transformation, NeoplasticCytokinesEpithelial CellsInflammationLungLung NeoplasmsMiceNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIProstaglandinsConceptsMouse lung epithelial cell lineLung epithelial cell lineInducible NO synthaseBiosynthetic enzymesEpithelial cell lineCell linesProstaglandin E2Lung tumor-derived cell linesTumor-derived cell linesNon-tumorigenic linesNitric oxidePG biosynthetic enzymesCytokine exposureInhibition of iNOSNormal lung cellsCyclooxygenase-2 activityPhysiological relevanceLung tumor formationLung tumor growthMouse lung tumorsSpontaneous transformantsTumor formationCritical mediatorControl lungsEpithelial cells