2025
Hierarchical Multi‐Label Classification With Gene‐Environment Interactions in Disease Modeling
Li J, Zhang Q, Ma S, Fang K, Xu Y. Hierarchical Multi‐Label Classification With Gene‐Environment Interactions in Disease Modeling. Statistics In Medicine 2025, 44: e10330. PMID: 39865593, PMCID: PMC12201914, DOI: 10.1002/sim.10330.Peer-Reviewed Original ResearchConceptsHierarchical multi-label classificationMulti-label classificationGene-environment interaction analysisGene-environmentEfficient expectation-maximizationGene-environment interactionsSemi-supervised scenariosCancer Genome AtlasUnlabeled dataInteraction analysisExpectation-maximizationGenome AtlasSuperior performanceHierarchical responseDisease outcomeClassificationPenalized estimatorsPractice settingsDisease modelsBiomedical studiesAnalysis literatureE effects
2024
High-Dimensional Gene–Environment Interaction Analysis
Wu M, Li Y, Ma S. High-Dimensional Gene–Environment Interaction Analysis. Annual Review Of Statistics And Its Application 2024, 12: 361-383. PMID: 40881670, PMCID: PMC12383825, DOI: 10.1146/annurev-statistics-112723-034315.Peer-Reviewed Original ResearchFixed- and random-effects analysisG-E interaction analysisG-E interactionsVariable selectionFrequentist analysisGene-environmentRandom effects analysisGeneral frameworkStatistical propertiesProgression of complex diseasesDimension reductionHypothesis testingG-EComplex diseasesGenetic factorsInteraction analysisNonlinear effect analysisStatistical perspectiveDisease outcomeEnvironmental factorsPrediction-basedEstimation-based
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