2025
Mitochondrial tRNA fragment, mt-tRF-Tyr-GTA-001 (tRF-21-X3OJI8EWB), in breast cancer and its potential clinical implications
Wang J, Katsaros D, Wang Z, Ma L, Casetta E, Fei P, Denti P, Grimaudo I, Chen S, Deng Y, Yu H. Mitochondrial tRNA fragment, mt-tRF-Tyr-GTA-001 (tRF-21-X3OJI8EWB), in breast cancer and its potential clinical implications. Breast Cancer Research And Treatment 2025, 211: 675-685. PMID: 40102335, DOI: 10.1007/s10549-025-07682-x.Peer-Reviewed Original ResearchConceptsBreast tumorsInvolvement of tRNARegulation of cell phenotypeSuppress breast cancer progressionSmall non-coding RNAsIn silico analysisOncogenic transcription factorHormone receptor statusCox proportional hazards regressionMitochondrial tRNAsBreast cancer progressionCleaves tRNATRNA fragmentsProportional hazards regressionRNase 4Non-coding RNAsPotential clinical implicationsResting mast cellsTranscription factorsSilico analysisReceptor statusTumor immunityQuantitative RT-PCRTRNATumor grade
2016
Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer
Feng N, Ching T, Wang Y, Liu B, Lin H, Shi O, Zhang X, Zheng M, Zheng X, Gao M, Zheng Z, Yu H, Garmire L, Qian B. Analysis of Microarray Data on Gene Expression and Methylation to Identify Long Non-coding RNAs in Non-small Cell Lung Cancer. Scientific Reports 2016, 6: 37233. PMID: 27849024, PMCID: PMC5110979, DOI: 10.1038/srep37233.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsCarcinoma, Non-Small-Cell LungCell LineCell Line, TumorCell ProliferationDisease ProgressionDNA MethylationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHEK293 CellsHumansLung NeoplasmsMaleOligonucleotide Array Sequence AnalysisRNA InterferenceRNA, Long NoncodingSurvival AnalysisConceptsDNA methylationGene expressionMicroarray dataGenome-wide expressionLong non-coding RNALong non-coding RNAsNon-coding RNANon-coding RNAsGene expression chipsNon-tumor tissuesAdditional tumor samplesCancer-related genesLOC146880Progression of NSCLCExpression chipsDifferential expressionLncRNA expressionMethylationTumor samplesLncRNAsAdjacent non-tumor tissuesTumor cellsCell proliferationRT-qPCRGenes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply