2025
GWAS meta-analysis identifies five susceptibility loci for endometrial cancer
Ramachandran D, Wang X, Laisk T, Zheng Y, Ingold N, Canson D, Kho P, Naumann B, Chapman C, Bousset K, Krause A, Schürmann P, Wieland B, Hanel P, Hülse F, Häfner N, Runnebaum I, Dubrowinskaja N, Turmanov N, Yugay T, Yessimsiitova Z, Amant F, Annibali D, Beckmann M, Bodelon C, Buchanan D, Chen C, Clarke M, Cook L, De Vivo I, De Wispelaere W, Du M, Easton D, Emons J, Fasching P, Friedenreich C, Gallagher G, Giles G, Goode E, Harris H, Hunter D, Kolin D, Kraft P, Lacey J, Lambrechts D, Lu L, Mutter G, Naduparambil J, O’Connell K, Patel A, Pharoah P, Rebbeck T, Ricceri F, Risch H, Ruebner M, Sacerdote C, Scott R, Setiawan V, Shu X, Southey M, Tham E, Tomlinson I, Turman C, Wentzensen N, Xu W, Yu H, Zheng W, Spurdle A, Yarden Y, Team E, Mägi R, Hillemanns P, Glubb D, Dörk T, O’Mara T. GWAS meta-analysis identifies five susceptibility loci for endometrial cancer. EBioMedicine 2025, 118: 105830. PMID: 40633141, PMCID: PMC12275056, DOI: 10.1016/j.ebiom.2025.105830.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study meta-analysisRisk lociGenome-wide association study analysisGenome-wide significant risk lociTumor suppressorNeuron navigator 3Significant risk lociGene-based analysisEndometrial Cancer Association ConsortiumSignificant lociValidation genotypingAssociation studiesSusceptibility lociMeta-analysisEndometrial cancer casesCell divisionHigh-income countriesLociEnvironmental risk factorsCell deathCell survivalEndometrial cancerNAV3Case-control series
2010
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tjønneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nature Genetics 2010, 42: 224-228. PMID: 20101243, PMCID: PMC2853179, DOI: 10.1038/ng.522.Peer-Reviewed Original Research
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