Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis
Ong J, An J, Han X, Law M, Nandakumar P, team 2, consortium E, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen C, Neale R, Fitzgerald R, Thrift A, Vaughan T, Buas M, Hinds D, Gharahkhani P, Kendall B, MacGregor S, consortium E, Fitzgerald R, Buas M, Gammon M, Corley D, Shaheen N, Hardie L, Bird N, Reid B, Chow W, Risch H, Ye W, Liu G, Romero Y, Bernstein L, Wu A, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Whiteman D, team 2, Agee M, Aslibekyan S, Auton A, Bell R, Bryc K, Clark S, Elson S, Fletez-Brant K, Fontanillas P, Furlotte N, Gandhi P, Heilbron K, Hicks B, Hinds D, Huber K, Jewett E, Jiang Y, Kleinman A, Lin K, Litterman N, Luff M, McCreight J, McIntyre M, McManus K, Mountain J, Mozaffari S, Nandakumar P, Noblin E, Northover C, O'Connell J, Petrakovitz A, Pitts S, Poznik G, Sathirapongsasuti J, Shastri A, Shelton J, Shringarpure S, Tian C, Tung J, Tunney R, Vacic V, Wang X, Zare A. Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett’s oesophagus and provides insights into clinical heterogeneity in reflux diagnosis. Gut 2021, 71: 1053-1061. PMID: 34187846, PMCID: PMC9120377, DOI: 10.1136/gutjnl-2020-323906.Peer-Reviewed Original ResearchMeSH KeywordsBarrett EsophagusEsophageal NeoplasmsEsophagitis, PepticGastroesophageal RefluxGenome-Wide Association StudyHumansObesity
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