Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer
Li D, Duell EJ, Yu K, Risch HA, Olson SH, Kooperberg C, Wolpin BM, Jiao L, Dong X, Wheeler B, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Hartge P, Hoover RN, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Mandelson MT, Petersen G, Zheng W, Agalliu I, Albanes D, Boutron-Ruault MC, Bracci PM, Buring JE, Canzian F, Chang K, Chanock SJ, Cotterchio M, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Bolton J, Hunter DJ, Hutchinson A, Jacobs KB, Jenab M, Khaw KT, Kraft P, Krogh V, Kurtz RC, McWilliams RR, Mendelsohn JB, Patel AV, Rabe KG, Riboli E, Shu XO, Tjønneland A, Tobias GS, Trichopoulos D, Virtamo J, Visvanathan K, Watters J, Yu H, Zeleniuch-Jacquotte A, Amundadottir L, Stolzenberg-Solomon RZ. Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. Carcinogenesis 2012, 33: 1384-1390. PMID: 22523087, PMCID: PMC3405651, DOI: 10.1093/carcin/bgs151.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGWAS dataPancreatic developmentSingle nucleotide polymorphismsBiological pathwaysDisease-associated single nucleotide polymorphismsGenome-wide association study dataOriginal genome-wide association studiesGroup of genesPathway-based analysisAssociation study dataSingle-locus methodPathway-based approachDevelopment genesGenetic risk variantsPathway analysisInherited variationSignificant genesAssociation studiesGenesRisk variantsAdaptive rankNominal associationPathwayHNF4G
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