2025
Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile
Hunt R, Oh J, Jain A, Kuo T, Berardi D, Jian W, Song D, Wu Q, Goodman A, Palm N, Zimmermann M, Johnson C, Crawford J. Discovery of a Widespread Polyamine–Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile. ACS Infectious Diseases 2025, 11: 2246-2264. PMID: 40671632, PMCID: PMC12403189, DOI: 10.1021/acsinfecdis.5c00286.Peer-Reviewed Original ResearchConceptsLow-molecular-weight thiolsTwo-gene operonBacteroides uniformisExpression of polyaminesAssociated with diseaseColorectal cancerBiosynthesis genesCommunity-level changesClostridioides difficile infectionGut homeostasisGenetic screeningGI mucosal biopsiesRisk of colorectal cancerHybrid pathwayMicrobial metabolismHybrid metabolitesGastrointestinal (GI) tractClostridioides difficileDiverse collectionHost immunityMucosal biopsiesSevere inflammationGenesCationic metabolitesMucolytic agent
2016
Metabolite and Microbiome Interplay in Cancer Immunotherapy
Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and Microbiome Interplay in Cancer Immunotherapy. Cancer Research 2016, 76: 6146-6152. PMID: 27729325, PMCID: PMC5093024, DOI: 10.1158/0008-5472.can-16-0309.Peer-Reviewed Original ResearchConceptsMicrobial interactionsRole of metabolitesCancer metabolismColon cancerHost microbiomeBiological originCancer progressionAdenoma/carcinomaPolysaccharide matrixTherapeutic designMetabolomic analysisPotential modulatorsMechanism of actionMicrobiomePolyamine metabolitesCancer immunotherapyBacteriaProximal colonBiofilmsProtective biofilmRecent studiesCancer treatmentMetabolismFuture targetsMetabolites
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