2025
Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase
Aladelokun O, Benitez K, Wang Y, Jain A, Berardi D, Maroun G, Shen X, Roper J, Gibson J, Sumigray K, Khan S, Johnson C. Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase. Pharmacological Research 2025, 215: 107736. PMID: 40228761, PMCID: PMC12100670, DOI: 10.1016/j.phrs.2025.107736.Peer-Reviewed Original ResearchTumor-specific survivalColorectal cancerTumor growthR2G2 miceIncreased serum estradiol levelsSerum estradiol levelsSub-populations of macrophagesAssociated with cancer prognosisSuppressed tumor growthColorectal tumor growthExogenous asparagineColorectal cancer developmentColorectal cancer cellsNegative feed-back effectEstradiol levelsGlutamate levelsSex-related differencesSex-specific effectsMale miceCancer prognosisAsparagine supplementationCancer progressionMiceDecreased numberTumor
2021
Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach
Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicological Sciences 2021, 183: 338-351. PMID: 33693819, PMCID: PMC8921626, DOI: 10.1093/toxsci/kfab030.Peer-Reviewed Original ResearchConceptsDX exposureBile acid quantificationRepair responseBDF-1 miceDNA damageDose-dependent DNA damageEffects of exposureHistopathological studySubchronic exposureImmunohistochemical analysisLiver carcinogenLiver carcinogenicityLiver transcriptomicsDrinking waterMetabolomic profilingMicePotential mechanismsLiverEnvironmental chemicalsState maximum contaminant levelToxic effectsCell deathExposureOxidative stress responsePresent study
2012
Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics
Johnson CH, Slanař O, Krausz KW, Kang DW, Patterson AD, Kim JH, Luecke H, Gonzalez FJ, Idle JR. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics. American Journal Of Clinical Nutrition 2012, 96: 818-830. PMID: 22952181, PMCID: PMC3441109, DOI: 10.3945/ajcn.112.042929.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultalpha-TocopherolAmino AcidsAnimalsCholesterolChromansChromatography, High Pressure LiquidFemaleGlucuronidesHumansLiverMaleMetabolomicsMiceMice, Inbred C57BLMolecular StructureSpecies SpecificitySpectrometry, Mass, Electrospray IonizationTaurineVitamin E DeficiencyYoung AdultConceptsVitamin EUrinary metabolitesMass spectrometry-based metabolomicsNovel urinary metaboliteLiver fatty acidLiver cholesterolC57BL/6 miceChronic diseasesClinical trialsΑ-tocopherolMouse modelNovel metabolitesVitamin E.Human volunteersDietary supplementsUltraperformance liquid chromatographyMiceSerum samplesInterindividual variationLiver samplesDosingSerumUrineFatty acidsMetabolites
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