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Peter Krause, MD

Senior Research Scientist in Epidemiology (Microbial Diseases), in Medicine (Infectious Diseases) and in Pediatrics (Infectious Disease) and Lecturer in Epidemiology (Microbial Diseases)

Contact Information

Peter Krause, MD

Office Location

Mailing Address

  • Epidemiology of Microbial Diseases

    PO Box 208034, 60 College Street

    New Haven, CT 06520-8034

    United States

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Research Summary

Dr. Krause’s research interests are in vector borne diseases including babesiosis, Lyme disease and Borrelia miyamotoi, a relapsing fever spirochete. Current projects include babesiosis and Lyme disease persistence, co-infection, and geographic expansion; the host immunologic response to Babesia microti; prevention of transmission of babesiosis through blood transfusion; and human infection with Borrelia miyamotoi.

Specialized Terms: Vector borne diseases

Extensive Research Description

Dr. Krause’s research interests are in vector borne diseases including babesiosis, Lyme disease and Borrelia miyamotoi, a relapsing fever spirochete. Current projects include babesiosis and Lyme disease persistence, co-infection, and geographic expansion; the host immunologic response to Babesia microti; prevention of transmission of babesiosis through blood transfusion; and human infection with Borrelia miyamotoi.

Coauthors

Research Interests

Babesiosis; Blood Transfusion; Epidemiology; Lyme Disease; Relapsing Fever; Borrelia burgdorferi; Infectious Disease Medicine; Biostatistics; Diseases

Public Health Interests

Infectious Diseases; Vector-borne Diseases; Tick-borne Diseases

Selected Publications

  • Management strategies for human babesiosis.Smith RP, Hunfeld KP, Krause PJ. Management strategies for human babesiosis. Expert Review Of Anti-infective Therapy 2020, 18: 625-636. PMID: 32268823, DOI: 10.1080/14787210.2020.1752193.
  • Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis.Krause PJ, Auwaerter PG, Bannuru RR, Branda JA, Falck-Ytter YT, Lantos PM, Lavergne V, Meissner HC, Osani MC, Rips JG, Sood SK, Vannier E, Vaysbrot EE, Wormser GP. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2021, 72: e49-e64. PMID: 33252652, DOI: 10.1093/cid/ciaa1216.
  • Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.Lantos PM, Rumbaugh J, Bockenstedt LK, Falck-Ytter YT, Aguero-Rosenfeld ME, Auwaerter PG, Baldwin K, Bannuru RR, Belani KK, Bowie WR, Branda JA, Clifford DB, DiMario FJ, Halperin JJ, Krause PJ, Lavergne V, Liang MH, Meissner HC, Nigrovic LE, Nocton JJJ, Osani MC, Pruitt AA, Rips J, Rosenfeld LE, Savoy ML, Sood SK, Steere AC, Strle F, Sundel R, Tsao J, Vaysbrot EE, Wormser GP, Zemel LS. Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2021, 72: e1-e48. PMID: 33417672, DOI: 10.1093/cid/ciaa1215.
  • Human babesiosis.Krause PJ. Human babesiosis. International Journal For Parasitology 2019, 49: 165-174. PMID: 30690090, DOI: 10.1016/j.ijpara.2018.11.007.
  • Seroprevalence of Borrelia burgdorferi, B. miyamotoi, and Powassan Virus in Residents Bitten by Ixodes Ticks, Maine, USA.Smith RP, Elias SP, Cavanaugh CE, Lubelczyk CB, Lacombe EH, Brancato J, Doyle H, Rand PW, Ebel GD, Krause PJ. Seroprevalence of Borrelia burgdorferi, B. miyamotoi, and Powassan Virus in Residents Bitten by Ixodes Ticks, Maine, USA. Emerging Infectious Diseases 2019, 25: 804-807. PMID: 30882312, PMCID: PMC6433028, DOI: 10.3201/eid2504.180202.
  • Persistence of Babesia microti Infection in Humans.Bloch EM, Kumar S, Krause PJ. Persistence of Babesia microti Infection in Humans. Pathogens (Basel, Switzerland) 2019, 8 PMID: 31319461, PMCID: PMC6789900, DOI: 10.3390/pathogens8030102.
  • Community-acquired and transfusion-transmitted babesiosis are increasing: why and what to do?Kumar S, Fish D, Krause PJ. Community-acquired and transfusion-transmitted babesiosis are increasing: why and what to do? Transfusion 2018, 58: 617-619. PMID: 29528151, DOI: 10.1111/trf.14518.
  • Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species.Krause PJ, Carroll M, Fedorova N, Brancato J, Dumouchel C, Akosa F, Narasimhan S, Fikrig E, Lane RS. Human Borrelia miyamotoi infection in California: Serodiagnosis is complicated by multiple endemic Borrelia species. PloS One 2018, 13: e0191725. PMID: 29420552, PMCID: PMC5805228, DOI: 10.1371/journal.pone.0191725.
  • Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study.Kadkhoda K, Dumouchel C, Brancato J, Gretchen A, Krause PJ. Human seroprevalence of Borrelia miyamotoi in Manitoba, Canada, in 2011-2014: a cross-sectional study. CMAJ Open 2017, 5: E690-E693. PMID: 28882852, PMCID: PMC5621960, DOI: 10.9778/cmajo.20170070.
  • Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences.Diuk-Wasser MA, Vannier E, Krause PJ. Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences. Trends In Parasitology 2016, 32: 30-42. PMID: 26613664, PMCID: PMC4713283, DOI: 10.1016/j.pt.2015.09.008.
  • Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2016, 31: 454-8. PMID: 26481763, DOI: 10.1002/jca.21429.
  • Transfusion-transmitted babesiosis: is it time to screen the blood supply?Levin AE, Krause PJ. Transfusion-transmitted babesiosis: is it time to screen the blood supply? Current Opinion In Hematology 2016, 23: 573-580. PMID: 27537475, PMCID: PMC5241272, DOI: 10.1097/MOH.0000000000000287.
  • Babesiosis.Vannier EG, Diuk-Wasser MA, Ben Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-70. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.
  • Borrelia miyamotoi infection in nature and in humans.Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clinical Microbiology And Infection : The Official Publication Of The European Society Of Clinical Microbiology And Infectious Diseases 2015, 21: 631-9. PMID: 25700888, PMCID: PMC4470780, DOI: 10.1016/j.cmi.2015.02.006.
  • Borrelia miyamotoi: The Newest Infection Brought to Us by Deer Ticks.Krause PJ, Barbour AG. Borrelia miyamotoi: The Newest Infection Brought to Us by Deer Ticks. Annals Of Internal Medicine 2015, 163: 141-2. PMID: 26053967, DOI: 10.7326/M15-1219.
  • Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice.Krause PJ, Hendrickson JE, Steeves TK, Fish D. Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. Transfusion 2015, 55: 593-7. PMID: 25251880, DOI: 10.1111/trf.12879.
  • Babesiosis in China, an emerging threat.Vannier E, Krause PJ. Babesiosis in China, an emerging threat. The Lancet. Infectious Diseases 2015, 15: 137-9. PMID: 25539585, DOI: 10.1016/S1473-3099(14)71062-X.
  • Borrelia miyamotoi. In response.Krause PJ, Barbour AG. Borrelia miyamotoi. In response. Annals Of Internal Medicine 2015, 163: 964. PMID: 26666795, DOI: 10.7326/L15-5188.
  • Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States.Krause PJ, Narasimhan S, Wormser GP, Barbour AG, Platonov AE, Brancato J, Lepore T, Dardick K, Mamula M, Rollend L, Steeves TK, Diuk-Wasser M, Usmani-Brown S, Williamson P, Sarksyan DS, Fikrig E, Fish D. Borrelia miyamotoi sensu lato seroreactivity and seroprevalence in the northeastern United States. Emerging Infectious Diseases 2014, 20: 1183-90. PMID: 24960072, PMCID: PMC4073859, DOI: 10.3201/eid2007.131587.
  • Monitoring human babesiosis emergence through vector surveillance New England, USA.Diuk-Wasser MA, Liu Y, Steeves TK, Folsom-O'Keefe C, Dardick KR, Lepore T, Bent SJ, Usmani-Brown S, Telford SR, Fish D, Krause PJ. Monitoring human babesiosis emergence through vector surveillance New England, USA. Emerging Infectious Diseases 2014, 20: 225-31. PMID: 24447577, PMCID: PMC3901474, DOI: 10.3201/eid2002.130644.
  • Human Borrelia miyamotoi infection in the United States.Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. The New England Journal Of Medicine 2013, 368: 291-3. PMID: 23323920, PMCID: PMC3934646, DOI: 10.1056/NEJMc1215469.
  • Cardiology patient pages. Lyme disease and the heart.Krause PJ, Bockenstedt LK. Cardiology patient pages. Lyme disease and the heart. Circulation 2013, 127: e451-4. PMID: 23429899, DOI: 10.1161/CIRCULATIONAHA.112.101485.
  • Neurological manifestations of human babesiosis.Usmani-Brown S, Halperin JJ, Krause PJ. Neurological manifestations of human babesiosis. Handbook Of Clinical Neurology 2013, 114: 199-203. PMID: 23829910, DOI: 10.1016/B978-0-444-53490-3.00014-5.
  • Preventing transfusion-transmitted babesiosis: preliminary experience of the first laboratory-based blood donor screening program.Young C, Chawla A, Berardi V, Padbury J, Skowron G, Krause PJ. Preventing transfusion-transmitted babesiosis: preliminary experience of the first laboratory-based blood donor screening program. Transfusion 2012, 52: 1523-9. PMID: 22452654, DOI: 10.1111/j.1537-2995.2012.03612.x.
  • Human babesiosis.Vannier E, Krause PJ. Human babesiosis. The New England Journal Of Medicine 2012, 366: 2397-407. PMID: 22716978, DOI: 10.1056/NEJMra1202018.
  • Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia.Platonov AE, Karan LS, Kolyasnikova NM, Makhneva NA, Toporkova MG, Maleev VV, Fish D, Krause PJ. Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. Emerging Infectious Diseases 2011, 17: 1816-23. PMID: 22000350, PMCID: PMC3310649, DOI: 10.3201/eid1710.101474.
  • Long-term Lyme disease antibiotic therapy beliefs among New England residents.Macauda MM, Erickson P, Miller J, Mann P, Closter L, Krause PJ. Long-term Lyme disease antibiotic therapy beliefs among New England residents. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2011, 11: 857-62. PMID: 21417921, DOI: 10.1089/vbz.2010.0116.
  • Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection.Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2010, 50: 381-6. PMID: 20047477, DOI: 10.1086/649859.
  • The problem of transfusion-transmitted babesiosis.Young C, Krause PJ. The problem of transfusion-transmitted babesiosis. Transfusion 2009, 49: 2548-50. PMID: 20163687, DOI: 10.1111/j.1537-2995.2009.02494.x.
  • Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection.Krause PJ, Grant-Kels JM, Tahan SR, Dardick KR, Alarcon-Chaidez F, Bouchard K, Visini C, Deriso C, Foppa IM, Wikel S. Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2009, 9: 603-10. PMID: 19196014, PMCID: PMC2883515, DOI: 10.1089/vbz.2008.0091.
  • Update on babesiosis.Vannier E, Krause PJ. Update on babesiosis. Interdisciplinary Perspectives On Infectious Diseases 2009, 2009: 984568. PMID: 19727410, PMCID: PMC2734943, DOI: 10.1155/2009/984568.
  • Human babesiosis.Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infectious Disease Clinics Of North America 2008, 22: 469-88, viii-ix. PMID: 18755385, PMCID: PMC3998201, DOI: 10.1016/j.idc.2008.03.010.
  • Persistent and relapsing babesiosis in immunocompromised patients.Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and relapsing babesiosis in immunocompromised patients. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2008, 46: 370-6. PMID: 18181735, DOI: 10.1086/525852.
  • Nosocomial transmission of human granulocytic anaplasmosis?Krause PJ, Wormser GP. Nosocomial transmission of human granulocytic anaplasmosis? JAMA 2008, 300: 2308-9. PMID: 19017920, DOI: 10.1001/jama.2008.665.
  • Shared features in the pathobiology of babesiosis and malaria.Krause PJ, Daily J, Telford SR, Vannier E, Lantos P, Spielman A. Shared features in the pathobiology of babesiosis and malaria. Trends In Parasitology 2007, 23: 605-10. PMID: 17988944, DOI: 10.1016/j.pt.2007.09.005.
  • Atovaquone and azithromycin treatment for babesiosis in an infant.Raju M, Salazar JC, Leopold H, Krause PJ. Atovaquone and azithromycin treatment for babesiosis in an infant. The Pediatric Infectious Disease Journal 2007, 26: 181-3. PMID: 17259886, DOI: 10.1097/01.inf.0000250622.11505.8f.
  • Serum reactivity against Borrelia burgdorferi OspA in patients with rheumatoid arthritis.Hsieh YF, Liu HW, Hsu TC, Wei JC, Shih CM, Krause PJ, Tsay GJ. Serum reactivity against Borrelia burgdorferi OspA in patients with rheumatoid arthritis. Clinical And Vaccine Immunology : CVI 2007, 14: 1437-41. PMID: 17881508, PMCID: PMC2168181, DOI: 10.1128/CVI.00151-07.
  • The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2006, 43: 1089-134. PMID: 17029130, DOI: 10.1086/508667.
  • Reinfection and relapse in early Lyme disease.Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A. Reinfection and relapse in early Lyme disease. The American Journal Of Tropical Medicine And Hygiene 2006, 75: 1090-4. PMID: 17172372.
  • Confirmation of tick bite by detection of antibody to Ixodes calreticulin salivary protein.Alarcon-Chaidez F, Ryan R, Wikel S, Dardick K, Lawler C, Foppa IM, Tomas P, Cushman A, Hsieh A, Spielman A, Bouchard KR, Dias F, Aslanzadeh J, Krause PJ. Confirmation of tick bite by detection of antibody to Ixodes calreticulin salivary protein. Clinical And Vaccine Immunology : CVI 2006, 13: 1217-22. PMID: 16928887, PMCID: PMC1656538, DOI: 10.1128/CVI.00201-06.
  • Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient.Clark IA, Budd AC, Hsue G, Haymore BR, Joyce AJ, Thorner R, Krause PJ. Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient. Malaria Journal 2006, 5: 69. PMID: 16887045, PMCID: PMC1552079, DOI: 10.1186/1475-2875-5-69.
  • Hypersensitivity to ticks and Lyme disease risk.Burke G, Wikel SK, Spielman A, Telford SR, McKay K, Krause PJ. Hypersensitivity to ticks and Lyme disease risk. Emerging Infectious Diseases 2005, 11: 36-41. PMID: 15705320, PMCID: PMC3294369, DOI: 10.3201/eid1101.040303.
  • Increasing health burden of human babesiosis in endemic sites.Krause PJ, McKay K, Gadbaw J, Christianson D, Closter L, Lepore T, Telford SR, Sikand V, Ryan R, Persing D, Radolf JD, Spielman A. Increasing health burden of human babesiosis in endemic sites. The American Journal Of Tropical Medicine And Hygiene 2003, 68: 431-6. PMID: 12875292.
  • Babesiosis diagnosis and treatment.Krause PJ. Babesiosis diagnosis and treatment. Vector Borne And Zoonotic Diseases (Larchmont, N.Y.) 2003, 3: 45-51. PMID: 12804380, DOI: 10.1089/153036603765627451.
  • Babesiosis in pregnancy.Feder HM, Lawlor M, Krause PJ. Babesiosis in pregnancy. The New England Journal Of Medicine 2003, 349: 195-6. PMID: 12853599, DOI: 10.1056/NEJM200307103490221.
  • Successful treatment of human granulocytic ehrlichiosis in children using rifampin.Krause PJ, Corrow CL, Bakken JS. Successful treatment of human granulocytic ehrlichiosis in children using rifampin. Pediatrics 2003, 112: e252-3. PMID: 12949322, DOI: 10.1542/peds.112.3.e252.
  • Babesiosis: similar to malaria but different.Lantos PM, Krause PJ. Babesiosis: similar to malaria but different. Pediatric Annals 2002, 31: 192-7. PMID: 11905293, DOI: 10.3928/0090-4481-20020301-10.
  • Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease.Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A. Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clinical Infectious Diseases : An Official Publication Of The Infectious Diseases Society Of America 2002, 34: 1184-91. PMID: 11941544, DOI: 10.1086/339813.
  • Babesiosis.Krause PJ. Babesiosis. The Medical Clinics Of North America 2002, 86: 361-73. PMID: 11982307, DOI: 10.1016/s0025-7125(03)00092-0.
  • Ehrlichiosis in children.Lantos PM, Krause PJ. Ehrlichiosis in children. Seminars In Pediatric Infectious Diseases 2002, 13: 249-56. PMID: 12491230, DOI: 10.1053/spid.2002.127200.
  • Atovaquone and azithromycin for the treatment of babesiosis.Krause PJ, Lepore T, Sikand VK, Gadbaw J, Burke G, Telford SR, Brassard P, Pearl D, Azlanzadeh J, Christianson D, McGrath D, Spielman A. Atovaquone and azithromycin for the treatment of babesiosis. The New England Journal Of Medicine 2000, 343: 1454-8. PMID: 11078770, DOI: 10.1056/NEJM200011163432004.
  • Persistent parasitemia after acute babesiosis.Krause PJ, Spielman A, Telford SR, Sikand VK, McKay K, Christianson D, Pollack RJ, Brassard P, Magera J, Ryan R, Persing DH. Persistent parasitemia after acute babesiosis. The New England Journal Of Medicine 1998, 339: 160-5. PMID: 9664092, DOI: 10.1056/NEJM199807163390304.
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