2025
Sex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Safdar B. Sex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry. IJC Heart & Vasculature 2025, 58: 101667. PMID: 40224648, PMCID: PMC11987697, DOI: 10.1016/j.ijcha.2025.101667.Peer-Reviewed Original ResearchCMD patientsUpregulation of immune pathwaysCardiovascular diseaseProximity extension assayBody mass indexRegulation of blood flowSex differencesProteomic profilingIschemic symptomsCAD patientsMass indexIncreased angiogenesisGlucose metabolic pathwaysDifferential protein expressionPatientsSex-specific pathwaysProtein expressionImmune pathwaysBlood flowBlood samplesPrecision medicineINSL3Metabolic pathwaysPathway analysisExtension assay
2023
Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits
Cheng Y, Justice A, Wang Z, Li B, Hancock D, Johnson E, Xu K. Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits. BMC Genomics 2023, 24: 556. PMID: 37730558, PMCID: PMC10510240, DOI: 10.1186/s12864-023-09661-2.Peer-Reviewed Original ResearchConceptsDNA methylationMultiple traitsPleiotropic effectsGenetic variantsAberrant DNA methylationPhenome-wide association studyCis-meQTLsComplex traitsRelevant traitsDNAm sitesEnrichment analysisMeQTLsAssociation studiesSignificant traitsTraitsImmune pathwaysMethylationNew insightsMendelian randomizationImmunological functionsGenesVariantsCausal rolePathwayCpG
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