Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025 PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.Peer-Reviewed Original ResearchSex-biased gene expressionClinical featuresGene expressionType 2 inflammationClinical features of asthmaFeatures of asthmaAssociated with differential gene expressionExpression levelsImmune dysfunctionLocal validation cohortAdult patientsGene expression databaseValidation cohortImmune cellsClinical correlatesDifferential gene expressionGene expression differencesLymphocyte proliferationAllergic responsesAdult subjectsGene expression effectsGenetic polymorphismsImmune allergic responsesBlood samplesFemale genomesSex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Safdar B. Sex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry. IJC Heart & Vasculature 2025, 58: 101667. PMID: 40224648, PMCID: PMC11987697, DOI: 10.1016/j.ijcha.2025.101667.Peer-Reviewed Original ResearchCMD patientsUpregulation of immune pathwaysCardiovascular diseaseProximity extension assayBody mass indexRegulation of blood flowSex differencesProteomic profilingIschemic symptomsCAD patientsMass indexIncreased angiogenesisGlucose metabolic pathwaysDifferential protein expressionPatientsSex-specific pathwaysProtein expressionImmune pathwaysBlood flowBlood samplesPrecision medicineINSL3Metabolic pathwaysPathway analysisExtension assay
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply