2025
Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025 PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.Peer-Reviewed Original ResearchSex-biased gene expressionClinical featuresGene expressionType 2 inflammationClinical features of asthmaFeatures of asthmaAssociated with differential gene expressionExpression levelsImmune dysfunctionLocal validation cohortAdult patientsGene expression databaseValidation cohortImmune cellsClinical correlatesDifferential gene expressionGene expression differencesLymphocyte proliferationAllergic responsesAdult subjectsGene expression effectsGenetic polymorphismsImmune allergic responsesBlood samplesFemale genomes
2023
Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical features
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply