2025
Urinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks
Qian J, Guo X, Qi C, Sun P, Li C, Li C, Cao K, Xu Y, Ren H, Zhang J, Wang Y, Bao S, Qiu T, Wang C, Gu W, Lu Y, Tong S, Tang S, Shi X. Urinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks. Journal Of Hazardous Materials 2025, 496: 139444. PMID: 40773834, DOI: 10.1016/j.jhazmat.2025.139444.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleMiddle AgedPolycyclic Aromatic HydrocarbonsRisk AssessmentConceptsPolycyclic aromatic hydrocarbonsHealth risksHazard indexOH-PAHsPAH exposureUrinary OH-PAH concentrationsDietary exposure routeNon-carcinogenic riskPolycyclic aromatic hydrocarbon exposureOH-PAH concentrationsHuman health risksHealth risk assessmentRisk assessmentCarcinogenic risk assessmentConsumption of drinking waterAromatic hydrocarbonsExposure routesPartial burningMitigation policiesMixed-effects modeling techniquesDrinking waterComprehensive exposureCorn productionShandong ProvinceCarbon-based materialsAssociations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study
Li C, Fang J, Xu Y, Yang J, Ren H, Cao K, Ding E, Wang Y, Li C, Zhang J, Guo X, Qian J, Lu Y, Tong S, Tang S, Shi X. Associations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study. Journal Of Hazardous Materials 2025, 495: 139069. PMID: 40582155, DOI: 10.1016/j.jhazmat.2025.139069.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChinaEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleMetabolomicsMiddle AgedOxidative StressPolycyclic Aromatic HydrocarbonsConceptsUrinary PAH metabolitesMonthly follow-up visitsPolycyclic aromatic hydrocarbonsReactive oxygen speciesFollow-up visitPotential mechanismsType 2 diabetesPolycyclic aromatic hydrocarbon exposureUrine metabolomePAH metabolitesMetabolic healthMetabolic perturbationsMetabolic disordersAdverse outcome pathwayOlder adultsAromatic hydrocarbonsDiverse cohortPolycyclic aromatic hydrocarbon compoundsOxidative stressMarkersMolecular initiating eventUrinary polycyclic aromatic hydrocarbonsOxygen speciesMetabolitesAdultsExposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study
Guo X, Qian J, Ren H, Ding E, Ma X, Zhang J, Qiu T, Lu Y, Sun P, Li C, Li C, Xu Y, Cao K, Lin X, Mao C, Tong S, Tang S, Shi X. Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study. Journal Of Hazardous Materials 2025, 488: 137365. PMID: 39869979, DOI: 10.1016/j.jhazmat.2025.137365.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaCosmeticsEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleMiddle AgedRisk AssessmentConceptsPersonal care productsHealthy older adultsHealth risksOlder adultsExposure to ambient PM2.5Benzophenone-2Ambient PM2.5Care productsHealth risks associated with exposureRisks associated with exposureAssociated health risksRisk of chemicalsHealth risks of chemicalsIncreased physical activityAssessment of older adultsMinimal health risksPhysical well-beingPredominant chemicalsMedian concentrationsPhysical activityExposure assessmentExposure profilesRisk assessmentExposure levelsMethyl paraben
2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChinaDyslipidemiasEast Asian PeopleEnvironmental ExposureEnvironmental PollutantsExposomeFemaleHumansLongitudinal StudiesMaleMiddle AgedConceptsDyslipidemia markersCardiovascular diseaseMulti-OmicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociations between serum per- and polyfluoroalkyl substances and thyroid hormones in Chinese adults: A nationally representative cross-sectional study
Xing Y, Li Z, Wang J, Qu Y, Hu Q, Ji S, Chang X, Zhao F, Lv Y, Pan Y, Shi X, Dai J. Associations between serum per- and polyfluoroalkyl substances and thyroid hormones in Chinese adults: A nationally representative cross-sectional study. Environment International 2024, 184: 108459. PMID: 38320373, DOI: 10.1016/j.envint.2024.108459.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlkanesulfonic AcidsBayes TheoremChinaCross-Sectional StudiesEnvironmental PollutantsFatty AcidsFemaleFluorocarbonsHumansMaleThyroid HormonesConceptsRestricted cubic splinesBayesian kernel machine regressionNationally representative cross-sectional studyNonlinear dose-response associationDose-response associationChinese adult populationWeighted multiple linear regressionGeneral Chinese populationCross-sectional studyNationally representative dataYounger age groupsKernel machine regressionChinese adultsInverse associationG-computationPerfluoroheptane sulfonic acidQuantile-based g-computationAdult populationRepresentative dataSignificant associationPositive associationThyroid homeostasisChinese populationMultiple linear regressionAge groups
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