Acute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China
Tian Y, Chen C, Li J, Liu S, Fang J, Zhao F, Tang S, Zhang Y, Du P, Wang J, Zhang Z, Li Y, Ding E, Liu Y, Wang F, Shi W, Sun Q, Hu J, Shi X. Acute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China. Ecotoxicology And Environmental Safety 2025, 303: 118976. PMID: 40925186, DOI: 10.1016/j.ecoenv.2025.118976.Peer-Reviewed Original ResearchConceptsImpacts of PM2.5Endocrine disrupting effectsBeijing-Tianjin-HebeiHeavy metalsAmbient fine particulate matterFine particulate matterAir pollutant concentrationsAssociated with thyroid hormone levelsThyroid hormone homeostasisPollutant concentrationsIQR increaseParticulate matterMonitoring stationsConstituent concentrationsParticulate constituentsThyroid homeostasisPbSurrounding areaMultiple linear regression modelZnHormone homeostasisThyroid hormone levelsMetalAssociated with T3Cd[Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China].
Wu C, Wang X, Chen Y, Li Z, Zhang Y, Wei Y, Wu B, Zhang W, Yang Z, Dong X, Hao R, Ye X, Wei L, Qu Y, Chu H, Lyu Y, Zhu Y, Xu D, Shi X. [Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China]. Chinese Preventive Medicine 2025, 59: 209-215. PMID: 39938993, DOI: 10.3760/cma.j.cn112150-20240625-00500.Peer-Reviewed Original ResearchConceptsThyroid hormone levelsRestricted cubic splinesUrinary cadmium levelsHormone levelsUrinary cadmiumFasting venous bloodAssociated with T3Dose-response relationshipMiddle-agedMidstream urineCadmium levelsUrine cadmium levelsMixed effects modelsLinear mixed effects modelsPositive nonlinear associationOlder adultsMulti-stage stratified random sampling methodPhysical examinationUrinary creatinineVenous bloodDietary frequencyDisease statusEffects modelOne-unit increaseCubic splines
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