2025
Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Zhong W, Wang X, Chen H, Song W, Gao J, Chen P, Shen Q, You F, Li C, Lv Y, Li Z, Shi X, Mao C. Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study. Alzheimer's Research & Therapy 2025, 17: 158. PMID: 40660329, PMCID: PMC12257734, DOI: 10.1186/s13195-025-01806-7.Peer-Reviewed Original ResearchConceptsCombined effects of physical activityEffects of physical activityPhysical activityApolipoprotein E genotypeRisk of cognitive impairmentHealthy dietHazard ratioCognitive impairmentOlder adultsDietary patternsActivity levelsLow risk of cognitive impairmentAdjusted Cox proportional hazards modelsMini-Mental State ExaminationNon-carriersOlder Chinese adultsApolipoprotein ELow riskCox proportional hazards modelsHigh PAProportional hazards modelDiet qualityCombination of activity levelMini-MentalChinese adults
2024
[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].
Zhong W, Wang X, Song W, Li C, Chen H, Chen Z, Lyu Y, Li Z, Shi X, Mao C. [Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China]. Chinese Journal Of Epidemiology 2024, 45: 41-47. PMID: 38228523, DOI: 10.3760/cma.j.cn112338-20231027-00254.Peer-Reviewed Original ResearchMeSH KeywordsAgedApolipoprotein E4Apolipoproteins ECognitionCognitive DysfunctionFrailtyHumansLife StyleConceptsCognitive frailtyCox proportional hazards regression modelsProportional hazards regression modelsPhysical activityHazards regression modelsHealthy lifestyleLevels of physical activityChinese Longitudinal Healthy Longevity SurveyElderly populationRegular physical activityDietary diversityLevel of dietary diversityAssociation of lifestyleAPOE geneImpact of lifestyleRegression modelsAdditive interactionAPOE e4 alleleLifestyle scoreCombined lifestyleLongevity SurveyPhysical frailtyStudy participantsElderly personsLifestyle
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