2025
Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study
Li C, Guo X, Ren H, Xu Y, Fang J, Sun P, Ding E, Lu Y, Li C, Zhao X, Long K, Cao K, Qian J, Chen Y, Wang Y, Deng F, Hou M, Shi Y, Cai Y, Tong S, Shen T, Tang S, Shi X. Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study. Environment & Health 2025 DOI: 10.1021/envhealth.5c00050.Peer-Reviewed Original ResearchOlder adultsHealthy older adultsOrganophosphate estersAdverse health outcomesGeriatric diseasesDiphenyl phosphateQuantile g-computationGeneralized Additive Mixed ModelsExposure to organophosphate estersBayesian kernel machine regressionHealth hazardsHealth outcomesOPE exposureKernel machine regressionAdditive mixed modelsG-computationDibutyl phosphateBis(1,3-dichloro-2-propyl) phosphateAssociation of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study
Wang X, Zhong W, Chen Z, Song W, You F, Li Z, Lv Y, Liu D, Shi X, Mao C. Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study. American Journal Of Clinical Nutrition 2025 PMID: 40876539, DOI: 10.1016/j.ajcnut.2025.08.013.Peer-Reviewed Original ResearchWeight-adjusted waist indexAssociated with frailty riskBody roundness indexAdiposity markersFrailty riskOlder adultsProspective cohort studyFrailty indexCohort studyHigh frailty riskSerum 25-hydroxyvitamin DWaist indexRoundness indexSerum 25(OH)DBody shape indexAssociation of adiposityFollow-upBody mass indexFrailty preventionJoint associationsWaist circumferenceBiomarkers Cohort StudyHealth deficitsLinear mixed modelsLow serum 25(OH)DThe Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study
Yang J, Huang J, Huang Q, Gao J, Liu D, Li Z, Lv Y, Shi X, Mao C. The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study. JMIR Aging 2025, 8: e75942. PMID: 40795324, PMCID: PMC12342692, DOI: 10.2196/75942.Peer-Reviewed Original ResearchCombined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Zhong W, Wang X, Chen H, Song W, Gao J, Chen P, Shen Q, You F, Li C, Lv Y, Li Z, Shi X, Mao C. Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study. Alzheimer's Research & Therapy 2025, 17: 158. PMID: 40660329, PMCID: PMC12257734, DOI: 10.1186/s13195-025-01806-7.Peer-Reviewed Original ResearchConceptsCombined effects of physical activityEffects of physical activityPhysical activityApolipoprotein E genotypeRisk of cognitive impairmentHealthy dietHazard ratioCognitive impairmentOlder adultsDietary patternsActivity levelsLow risk of cognitive impairmentAdjusted Cox proportional hazards modelsMini-Mental State ExaminationNon-carriersOlder Chinese adultsApolipoprotein ELow riskCox proportional hazards modelsHigh PAProportional hazards modelDiet qualityCombination of activity levelMini-MentalChinese adultsAssociation between vegetarian diet and risk of frailty in Chinese older adults: a prospective study
Huang Y, Jigeer G, Lv Y, Wang K, Ma X, Zou J, Xia R, Shen X, Shi X, Li Y, Gao X. Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study. BMC Medicine 2025, 23: 352. PMID: 40598166, PMCID: PMC12211529, DOI: 10.1186/s12916-025-04232-6.Peer-Reviewed Original ResearchConceptsRisk of frailtyChinese older adultsOlder adultsAssociated with higher riskFrailty riskDiet trajectoriesIncident frailtyAssociated with higher risk of frailtyChinese community-dwelling older adultsMultivariable time-varying Cox proportional hazards modelsChinese Longitudinal Healthy Longevity SurveyPesco-vegetariansCommunity-dwelling older adultsHigher risk of frailtyHazard ratioTime-varying Cox proportional hazards modelsConfidence intervalsRisk of incident frailtyFree of frailtyFood frequency questionnaireVegetarian dietHigher risk of incident frailtyHigh riskCox proportional hazards modelsLongevity SurveyPhysical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study
Xu L, Wang J, Li X, Li Y, Chen C, Xu Z, Xia Y, Lu Z, Zhou J, Zhang M, Wei Y, Wu B, Zhang Z, Li F, Luo Y, Chen G, Lv Y, Shi X. Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study. BMC Medicine 2025, 23: 361. PMID: 40598362, PMCID: PMC12220457, DOI: 10.1186/s12916-025-04176-x.Peer-Reviewed Original ResearchConceptsPhysical activityRegular exerciseOlder adultsLeisure activitiesHealth benefits of physical activityBenefits of physical activityChinese Longitudinal Health Longevity SurveyProspective community-based cohort studyGenetic riskCommunity-based cohort studyHazard ratioChinese older adultsPhysical workFace-to-face interviewsHigh leisure activityAll-Cause MortalityPA recommendationsPA informationLongevity SurveyFace-to-faceMedian scoreCohort studyExerciseCox proportional risk modelHealth benefitsAssociations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study
Li C, Fang J, Xu Y, Yang J, Ren H, Cao K, Ding E, Wang Y, Li C, Zhang J, Guo X, Qian J, Lu Y, Tong S, Tang S, Shi X. Associations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study. Journal Of Hazardous Materials 2025, 495: 139069. PMID: 40582155, DOI: 10.1016/j.jhazmat.2025.139069.Peer-Reviewed Original ResearchConceptsUrinary PAH metabolitesMonthly follow-up visitsPolycyclic aromatic hydrocarbonsReactive oxygen speciesFollow-up visitPotential mechanismsType 2 diabetesPolycyclic aromatic hydrocarbon exposureUrine metabolomePAH metabolitesMetabolic healthMetabolic perturbationsMetabolic disordersAdverse outcome pathwayOlder adultsAromatic hydrocarbonsDiverse cohortPolycyclic aromatic hydrocarbon compoundsOxidative stressMarkersMolecular initiating eventUrinary polycyclic aromatic hydrocarbonsOxygen speciesMetabolitesAdultsAssociations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China
Zhang Z, Zhao Y, Chen H, Qi L, Chen C, Wang J, Shi W, Lyu Y, Shi X. Associations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China. Biomedical And Environmental Sciences 2025, 38: 693-705. PMID: 40616485, DOI: 10.3967/bes2025.051.Peer-Reviewed Original ResearchConceptsOlder adultsMuscle massCommunity-dwelling older adultsAssociation of WBC countSkeletal muscle mass indexWhite blood cellsPlatelet countAssociation of white blood cellChinese older adultsMuscle mass indexManagement of sarcopeniaCross-sectional analysisMultivariate linear regressionBioelectrical impedance analysisInflammatory markersMuscle mass lossMonitoring of inflammatory markersPlatelet-to-white blood cell ratioBiomarkers Cohort StudyWBC countStratified analysisCohort studyBlood cellsMale participantsMass indexThree-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combinationAir Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights
Jiang M, Wang Y, Tian S, Liu S, Luo Y, Song H, Qin J, Lv Y, Baccarelli A, Zhang Z, Shi X, Gao X. Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights. Environmental Science And Technology 2025, 59: 9907-9917. PMID: 40353491, DOI: 10.1021/acs.est.4c13675.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity StudyAssociated with PM2.5 exposure inOlder adultsAir quality improvementHealth and Aging StudyClean Air ActEnvironmental policy interventionsQuasi-experimental studyRisk of worsening frailtyAir ActRange reductionKnowledge gapsLikelihood of improvementFrailty progressionNationwide cohortFollow-up visitFrailty burdenQuality improvementProspective cohortSurvey wavesAging StudyFrailtyMultistate modelling analysisFollow-up dataHealth benefits[Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis].
Zhao Y, Zhang Z, Wang J, Zhou J, Chen H, Qi L, Li Y, Chen Y, Meng X, Zhang Z, Chen C, Shi X, Lyu Y, Shi W. [Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis]. Chinese Journal Of Epidemiology 2025, 46: 746-752. PMID: 40494780, DOI: 10.3760/cma.j.cn112338-20241117-00729.Peer-Reviewed Original ResearchConceptsDietary behaviorsOlder adultsCategory scoresLatent class analysisDietary intakeFood intake frequencyRisk of sarcopeniaIncreased riskBalanced dietary patternFood frequency questionnaireIntake of cerealsMultivariate logistic regression modelChronic disease historyNon-sarcopenia groupLogistic regression modelsClass analysisIntake categoriesSARC-CalF.Frequency questionnaireBiomarkers Cohort StudyIntake frequencyDietary patternsSarcopenia groupCohort studyLongevity areas[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative association[Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China].
Hu X, Chen Y, Zhang Z, Chen C, Qu Y, Meng X, Wang J, Xu Z, Li Z, Liu S, Shi W, Xue Z, Long F, Shi X, Lyu Y. [Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China]. Chinese Preventive Medicine 2025, 59: 588-596. PMID: 40374347, DOI: 10.3760/cma.j.cn112150-20241231-01064.Peer-Reviewed Original ResearchConceptsPlant-based diet indexRisk of T2DMAssociated with T2DMMultivariate logistic regressionLongevity areasDiet indexOlder adultsPrevalence rates of T2DMSelf-health statusLogistic regressionFood intake frequencyRate of T2DMDietary behaviorsFood frequencyBiomarkers Cohort StudyIntake frequencyHigher adherenceType 2 diabetes mellitusFasting venous bloodHigh-level groupCohort studyLow-level groupPrevalence ratesDemographic characteristicsDaily activitiesVegetarian diet and healthy aging among Chinese older adults: a prospective study
Jigeer G, Wang K, Lv Y, Tucker K, Shen X, Chen F, Sun L, Shi X, Li Y, Gao X. Vegetarian diet and healthy aging among Chinese older adults: a prospective study. Npj Aging 2025, 11: 25. PMID: 40169599, PMCID: PMC11961757, DOI: 10.1038/s41514-025-00213-4.Peer-Reviewed Original ResearchOlder adultsHealthy agingDiet qualityChinese Longitudinal Healthy Longevity SurveyHealth effects of vegetarian dietsOlder Chinese adultsNon-quantitative food frequency questionnaireChinese older adultsHigher diet qualityFood frequency questionnaireOverall health statusEffects of vegetarian dietsHealthy older adultsVegetarian dietLongevity SurveyLifestyle factorsFrequency questionnaireChinese adultsHealth componentDietary patternsHealth effectsAdultsMedian Follow-UpIndividual outcomesFollow-upAssociation of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 PMID: 40155233, DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotideAssociation between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults
Guo X, Ren H, Zhang J, Ma X, Tong S, Tang S, Mao C, Shi X. Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults. Biomedical And Environmental Sciences 2025, 38: 144-153. PMID: 40159168, DOI: 10.3967/bes2025.015.Peer-Reviewed Original ResearchConceptsLung functionInflammatory factorsIL-13Hormone groupThyroid hormonesEffects of IL-2Organochlorine exposureHealthy older adultsInterleukin (IL)-2Thyroid hormone levelsAssociated with forced vital capacityOlder adultsForced Vital CapacityIL-7IL-2Hormone levelsIL-8Wearable passive samplersEffects of organochlorinesAssociated with changesVital capacityLungMediation analysisParticipants' lung functionBlood samples[Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China].
Wu C, Wang X, Chen Y, Li Z, Zhang Y, Wei Y, Wu B, Zhang W, Yang Z, Dong X, Hao R, Ye X, Wei L, Qu Y, Chu H, Lyu Y, Zhu Y, Xu D, Shi X. [Association of urine cadmium levels with thyroid hormone levels among middle-aged and older adults aged 40-89 years in selected areas of China]. Chinese Preventive Medicine 2025, 59: 209-215. PMID: 39938993, DOI: 10.3760/cma.j.cn112150-20240625-00500.Peer-Reviewed Original ResearchConceptsThyroid hormone levelsRestricted cubic splinesUrinary cadmium levelsHormone levelsUrinary cadmiumFasting venous bloodAssociated with T3Dose-response relationshipMiddle-agedMidstream urineCadmium levelsUrine cadmium levelsMixed effects modelsLinear mixed effects modelsPositive nonlinear associationOlder adultsMulti-stage stratified random sampling methodPhysical examinationUrinary creatinineVenous bloodDietary frequencyDisease statusEffects modelOne-unit increaseCubic splinesExposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study
Guo X, Qian J, Ren H, Ding E, Ma X, Zhang J, Qiu T, Lu Y, Sun P, Li C, Li C, Xu Y, Cao K, Lin X, Mao C, Tong S, Tang S, Shi X. Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study. Journal Of Hazardous Materials 2025, 488: 137365. PMID: 39869979, DOI: 10.1016/j.jhazmat.2025.137365.Peer-Reviewed Original ResearchConceptsPersonal care productsHealthy older adultsHealth risksOlder adultsExposure to ambient PM2.5Benzophenone-2Ambient PM2.5Care productsHealth risks associated with exposureRisks associated with exposureAssociated health risksRisk of chemicalsHealth risks of chemicalsIncreased physical activityAssessment of older adultsMinimal health risksPhysical well-beingPredominant chemicalsMedian concentrationsPhysical activityExposure assessmentExposure profilesRisk assessmentExposure levelsMethyl parabenAssociations of body mass index trajectories, weight change with mortality among the oldest old: do they differ from general older adults?
Qi L, Chen C, Zhou J, Liu S, Wang J, Wei Y, Shi W, Li Y, Zhang T, Lv Y, Shi X. Associations of body mass index trajectories, weight change with mortality among the oldest old: do they differ from general older adults? Science Bulletin 2025, 70: 1062-1065. PMID: 39966069, DOI: 10.1016/j.scib.2025.01.040.Peer-Reviewed Original ResearchBody mass index trajectoriesOlder adultsIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognition
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