2025
Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study
Li C, Guo X, Ren H, Xu Y, Fang J, Sun P, Ding E, Lu Y, Li C, Zhao X, Long K, Cao K, Qian J, Chen Y, Wang Y, Deng F, Hou M, Shi Y, Cai Y, Tong S, Shen T, Tang S, Shi X. Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study. Environment & Health 2025 DOI: 10.1021/envhealth.5c00050.Peer-Reviewed Original ResearchOlder adultsHealthy older adultsOrganophosphate estersAdverse health outcomesGeriatric diseasesDiphenyl phosphateQuantile g-computationGeneralized Additive Mixed ModelsExposure to organophosphate estersBayesian kernel machine regressionHealth hazardsHealth outcomesOPE exposureKernel machine regressionAdditive mixed modelsG-computationDibutyl phosphateBis(1,3-dichloro-2-propyl) phosphateVegetarian diet and healthy aging among Chinese older adults: a prospective study
Jigeer G, Wang K, Lv Y, Tucker K, Shen X, Chen F, Sun L, Shi X, Li Y, Gao X. Vegetarian diet and healthy aging among Chinese older adults: a prospective study. Npj Aging 2025, 11: 25. PMID: 40169599, PMCID: PMC11961757, DOI: 10.1038/s41514-025-00213-4.Peer-Reviewed Original ResearchOlder adultsHealthy agingDiet qualityChinese Longitudinal Healthy Longevity SurveyHealth effects of vegetarian dietsOlder Chinese adultsNon-quantitative food frequency questionnaireChinese older adultsHigher diet qualityFood frequency questionnaireOverall health statusEffects of vegetarian dietsHealthy older adultsVegetarian dietLongevity SurveyLifestyle factorsFrequency questionnaireChinese adultsHealth componentDietary patternsHealth effectsAdultsMedian Follow-UpIndividual outcomesFollow-upAssociation between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults
Guo X, Ren H, Zhang J, Ma X, Tong S, Tang S, Mao C, Shi X. Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults. Biomedical And Environmental Sciences 2025, 38: 144-153. PMID: 40159168, DOI: 10.3967/bes2025.015.Peer-Reviewed Original ResearchConceptsLung functionInflammatory factorsIL-13Hormone groupThyroid hormonesEffects of IL-2Organochlorine exposureHealthy older adultsInterleukin (IL)-2Thyroid hormone levelsAssociated with forced vital capacityOlder adultsForced Vital CapacityIL-7IL-2Hormone levelsIL-8Wearable passive samplersEffects of organochlorinesAssociated with changesVital capacityLungMediation analysisParticipants' lung functionBlood samplesExposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study
Guo X, Qian J, Ren H, Ding E, Ma X, Zhang J, Qiu T, Lu Y, Sun P, Li C, Li C, Xu Y, Cao K, Lin X, Mao C, Tong S, Tang S, Shi X. Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study. Journal Of Hazardous Materials 2025, 488: 137365. PMID: 39869979, DOI: 10.1016/j.jhazmat.2025.137365.Peer-Reviewed Original ResearchConceptsPersonal care productsHealthy older adultsHealth risksOlder adultsExposure to ambient PM2.5Benzophenone-2Ambient PM2.5Care productsHealth risks associated with exposureRisks associated with exposureAssociated health risksRisk of chemicalsHealth risks of chemicalsIncreased physical activityAssessment of older adultsMinimal health risksPhysical well-beingPredominant chemicalsMedian concentrationsPhysical activityExposure assessmentExposure profilesRisk assessmentExposure levelsMethyl paraben
2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-OmicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogramAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaPersonal exposure to airborne organic pollutants and lung function changes among healthy older adults
Guo X, Ren H, Sun P, Ding E, Fang J, Fang K, Ma X, Li C, Li C, Xu Y, Cao K, Lin E, Guo P, Pollitt K, Tong S, Tang S, Shi X. Personal exposure to airborne organic pollutants and lung function changes among healthy older adults. Environmental Research 2024, 258: 119411. PMID: 38876423, DOI: 10.1016/j.envres.2024.119411.Peer-Reviewed Original ResearchAssociation between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity
Shi W, Fang J, Ren H, Sun P, Liu J, Deng F, Zhang S, Wang Q, Wang J, Tong S, Tang S, Shi X. Association between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity. Journal Of Hazardous Materials 2024, 469: 134009. PMID: 38492399, DOI: 10.1016/j.jhazmat.2024.134009.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsChemical mixture exposureOrganophosphate estersPolyfluoroalkyl substancesMixture exposurePhysical activityAir pollution exposureExposure to chemical mixturesEffects of environmental chemicalsLevels of physical activityAromatic hydrocarbonsPollution exposureHealthy ageing strategiesAged care policyChemical mixturesHealthy older adultsEnvironmental chemicalsEpigenetic ageing biomarkersAdverse effects of environmental chemicalsAcceleration of population agingLifestyle factorsCare policyOlder adultsHormone homeostasisPhthalate
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