2025
Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Zhong W, Wang X, Chen H, Song W, Gao J, Chen P, Shen Q, You F, Li C, Lv Y, Li Z, Shi X, Mao C. Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study. Alzheimer's Research & Therapy 2025, 17: 158. PMID: 40660329, PMCID: PMC12257734, DOI: 10.1186/s13195-025-01806-7.Peer-Reviewed Original ResearchConceptsCombined effects of physical activityEffects of physical activityPhysical activityApolipoprotein E genotypeRisk of cognitive impairmentHealthy dietHazard ratioCognitive impairmentOlder adultsDietary patternsActivity levelsLow risk of cognitive impairmentAdjusted Cox proportional hazards modelsMini-Mental State ExaminationNon-carriersOlder Chinese adultsApolipoprotein ELow riskCox proportional hazards modelsHigh PAProportional hazards modelDiet qualityCombination of activity levelMini-MentalChinese adultsAssociation between vegetarian diet and risk of frailty in Chinese older adults: a prospective study
Huang Y, Jigeer G, Lv Y, Wang K, Ma X, Zou J, Xia R, Shen X, Shi X, Li Y, Gao X. Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study. BMC Medicine 2025, 23: 352. PMID: 40598166, PMCID: PMC12211529, DOI: 10.1186/s12916-025-04232-6.Peer-Reviewed Original ResearchConceptsRisk of frailtyChinese older adultsOlder adultsAssociated with higher riskFrailty riskDiet trajectoriesIncident frailtyAssociated with higher risk of frailtyChinese community-dwelling older adultsMultivariable time-varying Cox proportional hazards modelsChinese Longitudinal Healthy Longevity SurveyPesco-vegetariansCommunity-dwelling older adultsHigher risk of frailtyHazard ratioTime-varying Cox proportional hazards modelsConfidence intervalsRisk of incident frailtyFree of frailtyFood frequency questionnaireVegetarian dietHigher risk of incident frailtyHigh riskCox proportional hazards modelsLongevity SurveyPhysical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study
Xu L, Wang J, Li X, Li Y, Chen C, Xu Z, Xia Y, Lu Z, Zhou J, Zhang M, Wei Y, Wu B, Zhang Z, Li F, Luo Y, Chen G, Lv Y, Shi X. Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study. BMC Medicine 2025, 23: 361. PMID: 40598362, PMCID: PMC12220457, DOI: 10.1186/s12916-025-04176-x.Peer-Reviewed Original ResearchConceptsPhysical activityRegular exerciseOlder adultsLeisure activitiesHealth benefits of physical activityBenefits of physical activityChinese Longitudinal Health Longevity SurveyProspective community-based cohort studyGenetic riskCommunity-based cohort studyHazard ratioChinese older adultsPhysical workFace-to-face interviewsHigh leisure activityAll-Cause MortalityPA recommendationsPA informationLongevity SurveyFace-to-faceMedian scoreCohort studyExerciseCox proportional risk modelHealth benefitsThree-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combination
2024
Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
Song W, Zhong W, Gao J, Li Z, Ren J, Shen D, Wang X, Shen Q, You F, Fu Q, Li C, Chen H, Lv Y, Shi X, Mao C. Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study. International Journal Of Obesity 2024, 48: 1438-1446. PMID: 38926462, DOI: 10.1038/s41366-024-01571-x.Peer-Reviewed Original ResearchMetabolically unhealthy non-obeseMetabolically healthy non-obeseMetabolically Healthy ObesityMetabolic obesity phenotypesOldest-old populationMetabolically unhealthy obesityProspective cohort studyMortality riskCohort studyHazard ratioObese phenotypeManagement of metabolic healthUnhealthy non-obeseOldest-old adultsHealthy non-obeseMethodsThis prospective cohort studyDecreased mortality riskIncreased mortality riskHigher mortality riskYears of follow-upAll-Cause MortalityNon-obeseEffect of obesityHealthy obesityCentral obesityAssociations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China
Ni W, Lv Y, Yuan X, Zhang Y, Zhang H, Zheng Y, Shi X, Xu J. Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China. The Journal Of Clinical Endocrinology & Metabolism 2024, 110: e132-e139. PMID: 38436437, DOI: 10.1210/clinem/dgae116.Peer-Reviewed Original ResearchCause-specific mortalityAssociation of low-density lipoprotein cholesterolAll-CauseOlder adultsLDL-C levelsLow-density lipoprotein cholesterolAssociated with increased cancer mortalityHazard ratioRisk of all-cause mortalityCVD-specific mortalityLDL-CMultivariable-adjusted HRCardiovascular diseaseProspective cohort studyLipoprotein cholesterolAll-Cause MortalityCox proportional hazards modelsOther-cause mortalityHealthy aging researchProportional hazards modelCancer mortalityVital statusMultivariate Cox proportional hazards modelLow LDL-C levelsMedian follow-up time
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