Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights
Jiang M, Wang Y, Tian S, Liu S, Luo Y, Song H, Qin J, Lv Y, Baccarelli A, Zhang Z, Shi X, Gao X. Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights. Environmental Science And Technology 2025, 59: 9907-9917. PMID: 40353491, DOI: 10.1021/acs.est.4c13675.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity StudyAssociated with PM2.5 exposure inOlder adultsAir quality improvementHealth and Aging StudyClean Air ActEnvironmental policy interventionsQuasi-experimental studyRisk of worsening frailtyAir ActRange reductionKnowledge gapsLikelihood of improvementFrailty progressionNationwide cohortFollow-up visitFrailty burdenQuality improvementProspective cohortSurvey wavesAging StudyFrailtyMultistate modelling analysisFollow-up dataHealth benefitsAssociation of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 PMID: 40155233, DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotide
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