2025
Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combination
2024
[Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China].
Zhou J, Qi L, Wang J, Liu S, Shi W, Ye L, Zhang Z, Zhang Z, Meng X, Cui J, Chen C, Lyu Y, Shi X. [Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China]. Chinese Journal Of Epidemiology 2024, 45: 809-816. PMID: 38889980, DOI: 10.3760/cma.j.cn112338-20231205-00333.Peer-Reviewed Original ResearchConceptsDaily living scoresPredictors of frailtyArea under the receiver operating characteristic curveIncident frailtyOlder adultsLiving scoresChinese Longitudinal Healthy Longevity SurveyRisk thresholdSelf-rated healthChinese older adultsRisk of incident frailtyRisk of frailtyFree of frailtyPhysical examination variablesCox proportional hazards regression modelsProportional hazards regression modelsRisk prediction modelInstrumental activitiesHazards regression modelsLongevity SurveyFrailty incidenceFollow-up timeDecision-curve analysisOlder personsReceiver operating characteristic curve[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].
Zhong W, Wang X, Song W, Li C, Chen H, Chen Z, Lyu Y, Li Z, Shi X, Mao C. [Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China]. Chinese Journal Of Epidemiology 2024, 45: 41-47. PMID: 38228523, DOI: 10.3760/cma.j.cn112338-20231027-00254.Peer-Reviewed Original ResearchConceptsCognitive frailtyCox proportional hazards regression modelsProportional hazards regression modelsPhysical activityHazards regression modelsHealthy lifestyleLevels of physical activityChinese Longitudinal Healthy Longevity SurveyElderly populationRegular physical activityDietary diversityLevel of dietary diversityAssociation of lifestyleAPOE geneImpact of lifestyleRegression modelsAdditive interactionAPOE e4 alleleLifestyle scoreCombined lifestyleLongevity SurveyPhysical frailtyStudy participantsElderly personsLifestyle
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