2025
Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study
Wang X, Zhong W, Chen Z, Song W, You F, Li Z, Lv Y, Liu D, Shi X, Mao C. Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study. American Journal Of Clinical Nutrition 2025 PMID: 40876539, DOI: 10.1016/j.ajcnut.2025.08.013.Peer-Reviewed Original ResearchWeight-adjusted waist indexAssociated with frailty riskBody roundness indexAdiposity markersFrailty riskOlder adultsProspective cohort studyFrailty indexCohort studyHigh frailty riskSerum 25-hydroxyvitamin DWaist indexRoundness indexSerum 25(OH)DBody shape indexAssociation of adiposityFollow-upBody mass indexFrailty preventionJoint associationsWaist circumferenceBiomarkers Cohort StudyHealth deficitsLinear mixed modelsLow serum 25(OH)DThe Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study
Yang J, Huang J, Huang Q, Gao J, Liu D, Li Z, Lv Y, Shi X, Mao C. The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study. JMIR Aging 2025, 8: e75942. PMID: 40795324, PMCID: PMC12342692, DOI: 10.2196/75942.Peer-Reviewed Original ResearchPhysical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study
Xu L, Wang J, Li X, Li Y, Chen C, Xu Z, Xia Y, Lu Z, Zhou J, Zhang M, Wei Y, Wu B, Zhang Z, Li F, Luo Y, Chen G, Lv Y, Shi X. Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study. BMC Medicine 2025, 23: 361. PMID: 40598362, PMCID: PMC12220457, DOI: 10.1186/s12916-025-04176-x.Peer-Reviewed Original ResearchConceptsPhysical activityRegular exerciseOlder adultsLeisure activitiesHealth benefits of physical activityBenefits of physical activityChinese Longitudinal Health Longevity SurveyProspective community-based cohort studyGenetic riskCommunity-based cohort studyHazard ratioChinese older adultsPhysical workFace-to-face interviewsHigh leisure activityAll-Cause MortalityPA recommendationsPA informationLongevity SurveyFace-to-faceMedian scoreCohort studyExerciseCox proportional risk modelHealth benefitsAssociations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China
Zhang Z, Zhao Y, Chen H, Qi L, Chen C, Wang J, Shi W, Lyu Y, Shi X. Associations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China. Biomedical And Environmental Sciences 2025, 38: 693-705. PMID: 40616485, DOI: 10.3967/bes2025.051.Peer-Reviewed Original ResearchConceptsOlder adultsMuscle massCommunity-dwelling older adultsAssociation of WBC countSkeletal muscle mass indexWhite blood cellsPlatelet countAssociation of white blood cellChinese older adultsMuscle mass indexManagement of sarcopeniaCross-sectional analysisMultivariate linear regressionBioelectrical impedance analysisInflammatory markersMuscle mass lossMonitoring of inflammatory markersPlatelet-to-white blood cell ratioBiomarkers Cohort StudyWBC countStratified analysisCohort studyBlood cellsMale participantsMass indexThree-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combination[Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis].
Zhao Y, Zhang Z, Wang J, Zhou J, Chen H, Qi L, Li Y, Chen Y, Meng X, Zhang Z, Chen C, Shi X, Lyu Y, Shi W. [Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis]. Chinese Journal Of Epidemiology 2025, 46: 746-752. PMID: 40494780, DOI: 10.3760/cma.j.cn112338-20241117-00729.Peer-Reviewed Original ResearchConceptsDietary behaviorsOlder adultsCategory scoresLatent class analysisDietary intakeFood intake frequencyRisk of sarcopeniaIncreased riskBalanced dietary patternFood frequency questionnaireIntake of cerealsMultivariate logistic regression modelChronic disease historyNon-sarcopenia groupLogistic regression modelsClass analysisIntake categoriesSARC-CalF.Frequency questionnaireBiomarkers Cohort StudyIntake frequencyDietary patternsSarcopenia groupCohort studyLongevity areas[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative association[Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China].
Hu X, Chen Y, Zhang Z, Chen C, Qu Y, Meng X, Wang J, Xu Z, Li Z, Liu S, Shi W, Xue Z, Long F, Shi X, Lyu Y. [Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China]. Chinese Preventive Medicine 2025, 59: 588-596. PMID: 40374347, DOI: 10.3760/cma.j.cn112150-20241231-01064.Peer-Reviewed Original ResearchConceptsPlant-based diet indexRisk of T2DMAssociated with T2DMMultivariate logistic regressionLongevity areasDiet indexOlder adultsPrevalence rates of T2DMSelf-health statusLogistic regressionFood intake frequencyRate of T2DMDietary behaviorsFood frequencyBiomarkers Cohort StudyIntake frequencyHigher adherenceType 2 diabetes mellitusFasting venous bloodHigh-level groupCohort studyLow-level groupPrevalence ratesDemographic characteristicsDaily activities
2024
Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study
Zhu A, Kan H, Shi X, Zeng Y, Ji J. Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study. The Journals Of Gerontology Series A 2024, 80: glae302. PMID: 39716384, PMCID: PMC11897793, DOI: 10.1093/gerona/glae302.Peer-Reviewed Original ResearchConceptsProspective cohort studyNonaccidental mortalityChinese Longitudinal Healthy Longevity SurveyMortality riskCohort studyBlack carbonLow physical activityBC exposurePM2.5 componentsHighest effect estimatesAverage BCImprove public healthCox proportional hazards modelsPhysical activityLongevity SurveyPM2.5 exposure concentrationsFine particulate matterProportional hazards modelIncident mortalityStratified analysisPredictors of mortalityEffect estimatesRural populationDemographic covariatesPublic healthAssociation between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study
Wang X, Zhong W, Zhang Y, Xiang J, Chen H, Li Z, Shen Q, Shen D, Song W, Fu Q, Gao J, Chen Z, Li C, Xie J, Liu D, Lv Y, Shi X, Mao C. Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study. Nutrition Journal 2024, 23: 91. PMID: 39138490, PMCID: PMC11320915, DOI: 10.1186/s12937-024-00997-3.Peer-Reviewed Original ResearchConceptsDietary diversity scoreRisk of frailtyChinese older adultsOlder adultsSelf-reported health itemsChinese Longitudinal Healthy Longevity SurveyHigher risk of frailtyIncreased risk of frailtyOlder Chinese adultsFollow-up surveyNationwide cohort studyCox proportional hazards modelsHealth itemsLongevity SurveyFrailty incidencePrevent frailtyProportional hazards modelBackgroundDietary diversityChinese adultsFood groupsAssess frailtyPotential preventive measuresDiversity scoreComparing scoresCohort studyAnalysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study
Huang Q, Zhang P, Shen D, Gao J, Li Z, Lv Y, Shi X, Mao C. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study. Alzheimer's & Dementia 2024, 20: 5674-5683. PMID: 38946708, PMCID: PMC11350036, DOI: 10.1002/alz.14080.Peer-Reviewed Original ResearchAssociated with accelerated cognitive declineCognitive impairment riskPersistent lonelinessSocial isolationCognitive declineOlder adultsImpairment riskChinese Longitudinal Healthy Longevity SurveyIncident cognitive impairmentCognitive impairmentAssociation of changesNationwide cohort studyAccelerated cognitive declineCognitive functionLongevity SurveyCohort studyChanging statusLonelinessRisk factorsRegression modelsTobit regression modelCox modelShort-termRiskAdultsMetabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
Song W, Zhong W, Gao J, Li Z, Ren J, Shen D, Wang X, Shen Q, You F, Fu Q, Li C, Chen H, Lv Y, Shi X, Mao C. Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study. International Journal Of Obesity 2024, 48: 1438-1446. PMID: 38926462, DOI: 10.1038/s41366-024-01571-x.Peer-Reviewed Original ResearchMetabolically unhealthy non-obeseMetabolically healthy non-obeseMetabolically Healthy ObesityMetabolic obesity phenotypesOldest-old populationMetabolically unhealthy obesityProspective cohort studyMortality riskCohort studyHazard ratioObese phenotypeManagement of metabolic healthUnhealthy non-obeseOldest-old adultsHealthy non-obeseMethodsThis prospective cohort studyDecreased mortality riskIncreased mortality riskHigher mortality riskYears of follow-upAll-Cause MortalityNon-obeseEffect of obesityHealthy obesityCentral obesityHeat exposure induced risks of preterm birth mediated by maternal hypertension
Wang L, Di J, Wang Q, Zhang H, Zhao W, Shi X, Di Q, Ji J, Liang W, Huang C. Heat exposure induced risks of preterm birth mediated by maternal hypertension. Nature Medicine 2024, 30: 1974-1981. PMID: 38750350, DOI: 10.1038/s41591-024-03002-w.Peer-Reviewed Original ResearchRisk of maternal hypertensionRisk of preterm birthMaternal hypertensionPreterm birthClinical subtypes of preterm birthIncreased risk of preterm birthSubtypes of preterm birthIncidence of preterm birthBlood pressureMaternal blood pressureSingleton live birthsElevated blood pressureGestational weeksLarge-population studiesEarly pregnancyLive birthsClinical subtypesCohort studyIncreased riskHypertensionBirthMediation analysisEffects of heat exposureHeat exposureExposure[Association of sleep duration and physical exercise with dyslipidemia in older adults aged 80 years and over in China].
Wu B, Li Y, Xu L, Zhang Z, Zhou J, Wei Y, Chen C, Wang J, Wu C, Li Z, Hu Z, Long F, Wu Y, Hu X, Li K, Li F, Luo Y, Liu Y, Lyu Y, Shi X. [Association of sleep duration and physical exercise with dyslipidemia in older adults aged 80 years and over in China]. Chinese Journal Of Epidemiology 2024, 45: 48-55. PMID: 38228524, DOI: 10.3760/cma.j.cn112338-20231007-00207.Peer-Reviewed Original ResearchConceptsRestricted cubic splinesPhysical exerciseSleep durationPerson yearsDose-response relationshipAssociation of sleep durationPositive dose-response relationshipImpact of sleep durationBlood lipid testRisk of dyslipidemiaAverage sleep durationRestricted cubic spline functionsCompeting risk modelBaseline surveyBiomarkers Cohort StudyCases of dyslipidemiaLipid testingFasting venous blood samplesInteraction of sleep durationCohort studyExerciseCompetitive risk model analysisDemographic characteristicsIncidence densityStudy subjectsVitamin B12 is associated negatively with anemia in older Chinese adults with a low dietary diversity level: evidence from the Healthy Ageing and Biomarkers Cohort Study (HABCS)
Liu L, Zhou J, Chen C, Qu Y, Wang J, Lu F, Liu Y, Cai J, Ji S, Li Y, Gu H, Zhao F, Lyu Y, Shi X. Vitamin B12 is associated negatively with anemia in older Chinese adults with a low dietary diversity level: evidence from the Healthy Ageing and Biomarkers Cohort Study (HABCS). BMC Geriatrics 2024, 24: 18. PMID: 38178043, PMCID: PMC10768404, DOI: 10.1186/s12877-023-04586-7.Peer-Reviewed Original ResearchConceptsVitamin B12 levelsDietary diversity scorePlasma vitamin B12 levelsB12 levelsFood frequency questionnaireDifferent dietary patternsOlder adultsFrequency questionnaireDietary patternsHigh vitamin B12 levelsVitamin B12Low dietary diversity scoreHigh dietary diversity scorePrevalence of anemiaElderly Chinese peopleBiomarker cohort studyOlder Chinese adultsCohort studyAnemia statusDecreased riskMean ageAnemiaChinese adultsConclusionThe relationshipConfounding factors
2023
Atmospheric elemental carbon pollution and its regional health disparities in China
Hang Y, Meng X, Xi Y, Zhang D, Lin X, Liang F, Tian H, Li T, Wang T, Cao J, Fu Q, Dey S, Li S, Huang K, Kan H, Shi X, Liu Y. Atmospheric elemental carbon pollution and its regional health disparities in China. Environmental Research Letters 2023, 18: 124017. PMID: 39036363, PMCID: PMC11259311, DOI: 10.1088/1748-9326/ad0862.Peer-Reviewed Original Research
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