2025
Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study
Huang Y, Jigeer G, Lv Y, Wang K, Ma X, Zou J, Xia R, Shen X, Shi X, Li Y, Gao X. Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study. BMC Medicine 2025, 23: 352. PMID: 40598166, PMCID: PMC12211529, DOI: 10.1186/s12916-025-04232-6.Peer-Reviewed Original ResearchConceptsRisk of frailtyChinese older adultsOlder adultsAssociated with higher riskFrailty riskDiet trajectoriesIncident frailtyAssociated with higher risk of frailtyChinese community-dwelling older adultsMultivariable time-varying Cox proportional hazards modelsChinese Longitudinal Healthy Longevity SurveyPesco-vegetariansCommunity-dwelling older adultsHigher risk of frailtyHazard ratioTime-varying Cox proportional hazards modelsConfidence intervalsRisk of incident frailtyFree of frailtyFood frequency questionnaireVegetarian dietHigher risk of incident frailtyHigh riskCox proportional hazards modelsLongevity SurveyThree-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combinationVegetarian diet and healthy aging among Chinese older adults: a prospective study
Jigeer G, Wang K, Lv Y, Tucker K, Shen X, Chen F, Sun L, Shi X, Li Y, Gao X. Vegetarian diet and healthy aging among Chinese older adults: a prospective study. Npj Aging 2025, 11: 25. PMID: 40169599, PMCID: PMC11961757, DOI: 10.1038/s41514-025-00213-4.Peer-Reviewed Original ResearchOlder adultsHealthy agingDiet qualityChinese Longitudinal Healthy Longevity SurveyHealth effects of vegetarian dietsOlder Chinese adultsNon-quantitative food frequency questionnaireChinese older adultsHigher diet qualityFood frequency questionnaireOverall health statusEffects of vegetarian dietsHealthy older adultsVegetarian dietLongevity SurveyLifestyle factorsFrequency questionnaireChinese adultsHealth componentDietary patternsHealth effectsAdultsMedian Follow-UpIndividual outcomesFollow-upAssociation of social relationships and genetic risk with frailty
Song W, Zhong W, Yan H, Li Z, Gao J, Wang X, Chen P, You F, Li C, Chen H, Xie J, Lv Y, Shi X, Mao C. Association of social relationships and genetic risk with frailty. American Journal Of Geriatric Psychiatry 2025 PMID: 40155233, DOI: 10.1016/j.jagp.2025.02.015.Peer-Reviewed Original ResearchPolygenic risk scoresFrailty riskGenetic riskMendelian randomizationOlder adultsChinese Longitudinal Healthy Longevity SurveyTwo-sample Mendelian randomizationAssociations of social relationshipsSocial relationshipsEffects of social relationshipsSocial activitiesCox proportional hazards modelsIncreased frailty riskLongevity SurveyHigh frailty riskProportional hazards modelUnfavorable relationshipSocial supportTwo-time pointsRisk scoreFrailtyHazards modelGenetic susceptibilityAdditive interactionSingle-nucleotideIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognitionAir Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Zhu Q, Lyu Y, Huang K, Zhou J, Wang W, Steenland K, Chang H, Ebelt S, Shi X, Liu Y. Air Pollution and Cognitive Impairment Among the Chinese Elderly Population: An Analysis of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). GeoHealth 2025, 9: e2024gh001023. PMID: 39776607, PMCID: PMC11705411, DOI: 10.1029/2024gh001023.Peer-Reviewed Original ResearchChinese Longitudinal Health Longevity SurveyWarm-season O3Chinese elderly populationAssociated with cognitive impairmentLongevity SurveyCognitive impairmentLinear mixed-effects modelsChinese Longitudinal Healthy Longevity SurveyAir pollutionAssociation of air pollutionMixed-effects modelsAverage NO2Average PM2.5Elderly populationSingle-pollutant modelsMulti-pollutant modelsLogistic regression modelsCMMSE scoresControl Action PlanAir pollution preventionStudy participantsGaseous air pollutantsFollow-up visitRandom interceptPositive association
2024
Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study
Zhu A, Kan H, Shi X, Zeng Y, Ji J. Black Carbon Air Pollution and Incident Mortality Among the Advance-Aged Adults in China: A Prospective Cohort Study. The Journals Of Gerontology Series A 2024, 80: glae302. PMID: 39716384, PMCID: PMC11897793, DOI: 10.1093/gerona/glae302.Peer-Reviewed Original ResearchConceptsProspective cohort studyNonaccidental mortalityChinese Longitudinal Healthy Longevity SurveyMortality riskCohort studyBlack carbonLow physical activityBC exposurePM2.5 componentsHighest effect estimatesAverage BCImprove public healthCox proportional hazards modelsPhysical activityLongevity SurveyPM2.5 exposure concentrationsFine particulate matterProportional hazards modelIncident mortalityStratified analysisPredictors of mortalityEffect estimatesRural populationDemographic covariatesPublic healthSocial isolation and likelihood of becoming centenarians: evidence from the Chinese longitudinal healthy longevity survey
Li Y, Jigeer G, Lv Y, Wang K, Peng Y, Sun L, Shi X, Gao X. Social isolation and likelihood of becoming centenarians: evidence from the Chinese longitudinal healthy longevity survey. BMC Geriatrics 2024, 24: 839. PMID: 39407128, PMCID: PMC11476547, DOI: 10.1186/s12877-024-05417-z.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity SurveySocial isolationLongevity SurveyAssociated with health outcomesHigher social isolation scoresConditional logistic regression modelsOldest-old peopleProspective nested case-control studyPublic health initiativesSocial isolation scoresOldest-old populationNested Case-Control StudyDegree of social isolationLogistic regression modelsCase-control studyBackgroundSocial isolationHealth initiativesHealth outcomesLifestyle factorsCommunity-BasedNever smokersOlder adultsYear of entryInverse associationIsolation scoresLeisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study
Zhong W, Wang X, Liang F, Song W, Chen Z, Li Z, Shen Q, Shen D, Nan Y, Xiang J, Li C, Ye Z, Huang H, Wang J, Lv Y, Shi X, Mao C. Leisure-time activities and disability among Chinese community-dwelling oldest old: evidence from the Chinese Longitudinal Healthy Longevity Study. European Journal Of Public Health 2024, 34: 1177-1183. PMID: 39254527, PMCID: PMC11631485, DOI: 10.1093/eurpub/ckae129.Peer-Reviewed Original ResearchLeisure-time activitiesRisk of disabilityOlder adultsChinese Longitudinal Healthy Longevity StudyChinese Longitudinal Healthy Longevity SurveyActivities of daily livingChinese community-dwellingCox proportional hazards modelsPublic health problemLeisure-timeLongevity SurveyAcceleration of population agingCommunity-dwellingProportional hazards modelDaily livingPhysical performanceWatching TVHealth problemsFrequent engagementDaily activitiesAffecting disabilityDisabilityHazards modelPopulation agingLongevity StudyAssociation between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study
Wang X, Zhong W, Zhang Y, Xiang J, Chen H, Li Z, Shen Q, Shen D, Song W, Fu Q, Gao J, Chen Z, Li C, Xie J, Liu D, Lv Y, Shi X, Mao C. Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study. Nutrition Journal 2024, 23: 91. PMID: 39138490, PMCID: PMC11320915, DOI: 10.1186/s12937-024-00997-3.Peer-Reviewed Original ResearchConceptsDietary diversity scoreRisk of frailtyChinese older adultsOlder adultsSelf-reported health itemsChinese Longitudinal Healthy Longevity SurveyHigher risk of frailtyIncreased risk of frailtyOlder Chinese adultsFollow-up surveyNationwide cohort studyCox proportional hazards modelsHealth itemsLongevity SurveyFrailty incidencePrevent frailtyProportional hazards modelBackgroundDietary diversityChinese adultsFood groupsAssess frailtyPotential preventive measuresDiversity scoreComparing scoresCohort studyAnalysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study
Huang Q, Zhang P, Shen D, Gao J, Li Z, Lv Y, Shi X, Mao C. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study. Alzheimer's & Dementia 2024, 20: 5674-5683. PMID: 38946708, PMCID: PMC11350036, DOI: 10.1002/alz.14080.Peer-Reviewed Original ResearchAssociated with accelerated cognitive declineCognitive impairment riskPersistent lonelinessSocial isolationCognitive declineOlder adultsImpairment riskChinese Longitudinal Healthy Longevity SurveyIncident cognitive impairmentCognitive impairmentAssociation of changesNationwide cohort studyAccelerated cognitive declineCognitive functionLongevity SurveyCohort studyChanging statusLonelinessRisk factorsRegression modelsTobit regression modelCox modelShort-termRiskAdults[Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China].
Zhou J, Qi L, Wang J, Liu S, Shi W, Ye L, Zhang Z, Zhang Z, Meng X, Cui J, Chen C, Lyu Y, Shi X. [Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China]. Chinese Journal Of Epidemiology 2024, 45: 809-816. PMID: 38889980, DOI: 10.3760/cma.j.cn112338-20231205-00333.Peer-Reviewed Original ResearchConceptsDaily living scoresPredictors of frailtyArea under the receiver operating characteristic curveIncident frailtyOlder adultsLiving scoresChinese Longitudinal Healthy Longevity SurveyRisk thresholdSelf-rated healthChinese older adultsRisk of incident frailtyRisk of frailtyFree of frailtyPhysical examination variablesCox proportional hazards regression modelsProportional hazards regression modelsRisk prediction modelInstrumental activitiesHazards regression modelsLongevity SurveyFrailty incidenceFollow-up timeDecision-curve analysisOlder personsReceiver operating characteristic curveHealthy Lifestyle and the Likelihood of Becoming a Centenarian
Li Y, Wang K, Jigeer G, Jensen G, Tucker K, Lv Y, Shi X, Gao X. Healthy Lifestyle and the Likelihood of Becoming a Centenarian. JAMA Network Open 2024, 7: e2417931. PMID: 38900423, PMCID: PMC11190803, DOI: 10.1001/jamanetworkopen.2024.17931.Peer-Reviewed Original ResearchConceptsHealthy lifestyleCase-control studyLifestyle factorsOlder adultsChinese Longitudinal Healthy Longevity SurveySelf-reported chronic conditionsHealthy lifestyle scoreImprove lifestyle behaviorsChinese older adultsAssociated with life expectancyProspective nested case-control studyNested Case-Control StudyLifestyle scoreLifestyle behaviorsLongevity SurveyOlder age groupsHealth outcomesChronic conditionsSociodemographic characteristicsCommunity-BasedMental wellnessYear of entryMain OutcomesOdds ratioMiddle-agedBody mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study
Lv Y, Zhang Y, Li X, Gao X, Ren Y, Deng L, Xu L, Zhou J, Wu B, Wei Y, Cui X, Xu Z, Guo Y, Qiu Y, Ye L, Chen C, Wang J, Li C, Luo Y, Yin Z, Mao C, Yu Q, Lu H, Kraus V, Zeng Y, Tong S, Shi X. Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. European Heart Journal 2024, 45: 2145-2154. PMID: 38626306, PMCID: PMC11212828, DOI: 10.1093/eurheartj/ehae206.Peer-Reviewed Original ResearchChinese Longitudinal Healthy Longevity SurveyHigher Body Mass IndexAssociation of body mass indexBody mass indexNon-CVD mortalityOldest-old peopleWaist circumferenceOldest-oldMortality riskMendelian randomizationSingle-nucleotide polymorphismsInverse relationship of BMIStudies of body mass indexRelationship of body mass indexCardiovascular diseaseOptimal body mass indexMass indexAssociated with body mass indexCardiovascular disease mortalityMendelian randomization studiesAssociated with decreased mortality riskGenetic risk scoreNon-linear MR analysisLower mortality riskJoint effect analysis[Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China].
Zhong W, Wang X, Song W, Li C, Chen H, Chen Z, Lyu Y, Li Z, Shi X, Mao C. [Association of lifestyle and apolipoprotein E gene with risk for cognitive frailty in elderly population in China]. Chinese Journal Of Epidemiology 2024, 45: 41-47. PMID: 38228523, DOI: 10.3760/cma.j.cn112338-20231027-00254.Peer-Reviewed Original ResearchConceptsCognitive frailtyCox proportional hazards regression modelsProportional hazards regression modelsPhysical activityHazards regression modelsHealthy lifestyleLevels of physical activityChinese Longitudinal Healthy Longevity SurveyElderly populationRegular physical activityDietary diversityLevel of dietary diversityAssociation of lifestyleAPOE geneImpact of lifestyleRegression modelsAdditive interactionAPOE e4 alleleLifestyle scoreCombined lifestyleLongevity SurveyPhysical frailtyStudy participantsElderly personsLifestyle
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