2025
Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, PMCID: PMC11887085, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studies
2023
Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia.
Zhong C, Li S, Arroyo K, Morimoto L, de Smith A, Metayer C, Ma X, Kogan S, Gauderman W, Wiemels J. Gene-Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1707-1715. PMID: 37773025, PMCID: PMC11812055, DOI: 10.1158/1055-9965.epi-23-0258.Peer-Reviewed Original ResearchMeSH KeywordsDNA MethylationFemaleHumansInfant, NewbornMaternal ExposurePrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPrenatal Exposure Delayed EffectsSmokingTobacco Smoke PollutionTranscription FactorsConceptsMaternal tobacco exposureAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaTobacco exposureLymphoblastic leukemiaLarge population-based studyPopulation-based studyEffects of tobaccoPrenatal tobacco exposureAryl hydrocarbon receptor repressor geneMode of deliverySelf-reported smokingIndividual-level risk factorsGenetic variantsPolygenetic risk scoresYear of birthAHRR hypomethylationSubsequent childhoodMaternal exposureGestational ageRisk factorsTobacco smokeRisk scoreBiological markersBlood spots
2018
Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium
Petridou ET, Georgakis MK, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Ezzat S, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Rashed WM, Dessypris N, Schüz J, Infante-Rivard C, Skalkidou A. Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium. European Journal Of Epidemiology 2018, 33: 965-976. PMID: 29761423, PMCID: PMC6384148, DOI: 10.1007/s10654-018-0402-z.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMaternal AgeParentsPaternal AgePrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPrenatal Exposure Delayed EffectsRisk FactorsConceptsAcute lymphoblastic leukemiaChildhood Leukemia International ConsortiumChildhood acute lymphoblastic leukemiaCase-control studyAdvanced parental ageLymphoblastic leukemiaOdds ratioParental agePaternal ageAdvanced maternal ageSimilar positive associationPositive associationAdverse health effectsMaternal ageRisk factorsEnrollment periodStudy designAge incrementsHealth effectsFive yearsAgeUnderlying mechanismInternational ConsortiumLeukemiaRisk
2016
Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study
Symanski E, Tee Lewis PG, Chen TY, Chan W, Lai D, Ma X. Air toxics and early childhood acute lymphocytic leukemia in Texas, a population based case control study. Environmental Health 2016, 15: 70. PMID: 27301866, PMCID: PMC4908700, DOI: 10.1186/s12940-016-0154-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir PollutantsBenzeneButadienesCase-Control StudiesChild, PreschoolEnvironmental MonitoringFemaleHumansInfantInfant, NewbornMaleMaternal ExposureOdds RatioPolycyclic Aromatic HydrocarbonsPrecursor Cell Lymphoblastic Leukemia-LymphomaPregnancyPrenatal Exposure Delayed EffectsTexasYoung AdultConceptsAcute lymphocytic leukemiaCo-pollutant modelsCase-control studySingle-pollutant modelsChildhood leukemiaLymphocytic leukemiaChildhood acute lymphocytic leukemiaBirth certificatesCancer registry casesPopulation-based controlsEarly life exposureMixed effects logistic regression modelsEarly childhood risksLogistic regression modelsPotential confoundersEtiologic roleLowest quartileRegistry casesInfant characteristicsLife exposurePediatric cancerMaternal addressControl studyBirth recordsLeukemia
2013
Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype
Metayer C, Zhang L, Wiemels JL, Bartley K, Schiffman J, Ma X, Aldrich MC, Chang JS, Selvin S, Fu CH, Ducore J, Smith MT, Buffler PA. Tobacco Smoke Exposure and the Risk of Childhood Acute Lymphoblastic and Myeloid Leukemias by Cytogenetic Subtype. Cancer Epidemiology Biomarkers & Prevention 2013, 22: 1600-1611. PMID: 23853208, PMCID: PMC3769478, DOI: 10.1158/1055-9965.epi-13-0350.Peer-Reviewed Original ResearchConceptsChildren's passive smokingPassive smokingAcute lymphoblastic leukemiaTobacco smokeMyeloid leukemiaCytogenetic subtypesChildhood acute lymphoblastic leukemiaCHILDHOOD ACUTE LYMPHOBLASTICPaternal prenatal smokingPostnatal passive smokingTobacco smoke exposureRisk of childhoodMultivariable regression analysisTiming of exposureB cell precursorsHyperdiploid B cellsActive smokingPrenatal smokingTobacco smokingSmoke exposureLymphoblastic leukemiaAcute lymphoblasticAML casesElevated riskSmoking
2004
Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)
Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S. Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States). Cancer Causes & Control 2004, 15: 559-570. PMID: 15280635, DOI: 10.1023/b:caco.0000036161.98734.17.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaRisk factorsMaternal dietLymphoblastic leukemiaPopulation-based case-control studyChildhood acute lymphoblastic leukemiaConsumption of provitaminMaternal dietary intakeDietary risk factorsFood frequency questionnaireNorthern California Childhood Leukemia StudyCommon childhood cancerMaternal dietary factorsImportant risk factorCase-control studyCalifornia Childhood Leukemia StudyChildhood Leukemia StudyCounty of residenceConsumption of vegetablesDate of birthFrequency questionnaireDietary factorsChildhood cancerDietary intakeCommon cause
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