Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer
Janak A, Jain A, Garcia-Milian R, Aladelokun O, Ma X, Paty P, Khan S, Johnson C. Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer. Free Radical Biology And Medicine 2025, 240: 773-782. PMID: 40865779, DOI: 10.1016/j.freeradbiomed.2025.08.052.Peer-Reviewed Original ResearchLate-onset colorectal cancerEO-CRCColorectal cancerTumor metabolomeMass spectrometry-based untargeted metabolomicsTumor tissuesCatecholamine metabolismGroup of CRC patientsMetabolite set enrichment analysisPatient-matched normal tissuesTumor-specific differencesEarly-onset colorectal cancerMetabolite of dopaminePD-L1Untargeted metabolomicsCRC patientsOxidative stress-related genesHomovanillic acidGenetic alterationsEarly-onsetTumorTherapeutic strategiesGene expression validationNormal tissuesEGFR Signaling
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