2025
Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original ResearchAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesDepressionEmploymentFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causation
2024
Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)
Chen S, Underwood B, Cardinal R, Chen X, Chen S, Amin J, Jin H, Huang J, Mueller C, Yan L, Brayne C, Kuper H. Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019). BMC Medicine 2024, 22: 268. PMID: 38926751, PMCID: PMC11210022, DOI: 10.1186/s12916-024-03464-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingDementiaEnglandFemaleHumansLongitudinal StudiesMaleMiddle AgedRisk FactorsConceptsPopulation attributable fractionModifiable risk factorsEnglish Longitudinal Study of AgeingOverall PAFLongitudinal Study of AgingEnglish Longitudinal StudyPhysical inactivitySocioeconomic statusStudy of agingLower educationDementia riskSocial isolationAttributable fractionHearing lossRisk factorsTargeted public health strategiesTraumatic brain injuryProportion of dementiaDeterminants of dementiaSocioeconomic status categoriesEffective public health policiesDevelopment of evidence-basedPublic health strategiesPublic health policiesTime-series study
2020
How and to what extent can pensions facilitate increased use of health services by older people: evidence from social pension expansion in rural China
Chen S, Chen X, Law S, Lucas H, Tang S, Long Q, Xue L, Wang Z. How and to what extent can pensions facilitate increased use of health services by older people: evidence from social pension expansion in rural China. BMC Health Services Research 2020, 20: 1008. PMID: 33148248, PMCID: PMC7640495, DOI: 10.1186/s12913-020-05831-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overChinaHealth ServicesHumansLongitudinal StudiesMiddle AgedPensionsRetirementConceptsHealth service utilizationService utilizationHealth servicesOlder peopleFrequency of outpatientInpatient service useHealthcare-seeking behaviorRetirement Longitudinal StudyProportion of peopleTraditional Chinese medicineHealthcare utilisationService useEconomic burdenInpatient servicesAge groupsAdditional economic burdenChina HealthOlder adultsChinese medicineMethodsUsing dataLongitudinal studyOutpatientsRegression analysisState of healthFuzzy regression discontinuity designLinking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study
Li Y, Xue QL, Odden MC, Chen X, Wu C. Linking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study. Age And Ageing 2020, 49: 208-217. PMID: 31957780, PMCID: PMC7047816, DOI: 10.1093/ageing/afz160.Peer-Reviewed Original ResearchConceptsEarly life risk factorsLife risk factorsRisk factorsChildhood health statusRetirement Longitudinal StudyRisk differenceHealth statusChina HealthOlder ageOlder adultsAbsolute risk differenceCross-sectional studyLongitudinal studyUnfavorable socioeconomic statusLate-life frailtyWorse health conditionsChinese older adultsMiddle-income countriesDevelopment of diseaseHigh riskLower riskRepresentative cohortMultinomial regression modelsHealth conditionsFrailty
2019
Depression in the house: The effects of household air pollution from solid fuel use among the middle-aged and older population in China
Liu Y, Chen X, Yan Z. Depression in the house: The effects of household air pollution from solid fuel use among the middle-aged and older population in China. The Science Of The Total Environment 2019, 703: 134706. PMID: 31731156, PMCID: PMC9420076, DOI: 10.1016/j.scitotenv.2019.134706.Peer-Reviewed Original ResearchConceptsHigher CES-D scoresHousehold air pollutionSolid fuel usersCES-D scoresDepression riskPotential confoundersSolid fuel useEpidemiologic Studies Depression Scale scoreHAP exposureOlder populationFuel usersChronic lung diseaseClean fuel usersDepression Scale scoresPublic health effortsAmbient air pollutionHousehold solid fuel useAdverse health effectsLung diseaseDepression outcomesChronic diseasesCardiovascular diseaseHealth effortsScale scoreHealth statusAssociations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS Health
2018
Does money relieve depression? Evidence from social pension expansions in China
Chen X, Wang T, Busch SH. Does money relieve depression? Evidence from social pension expansions in China. Social Science & Medicine 2018, 220: 411-420. PMID: 30530234, PMCID: PMC6800113, DOI: 10.1016/j.socscimed.2018.12.004.Peer-Reviewed Original ResearchMeSH KeywordsChinaDepressionFemaleHumansIncomeLongitudinal StudiesMaleMiddle AgedPensionsRural PopulationSelf ReportSocio-Economic Inequalities in Tobacco Consumption of the Older Adults in China: A Decomposition Method
Si Y, Zhou Z, Su M, Wang X, Li D, Wang D, He S, Hong Z, Chen X. Socio-Economic Inequalities in Tobacco Consumption of the Older Adults in China: A Decomposition Method. International Journal Of Environmental Research And Public Health 2018, 15: 1466. PMID: 29997376, PMCID: PMC6069145, DOI: 10.3390/ijerph15071466.Peer-Reviewed Original ResearchConceptsTobacco consumptionConcentration indexNon-communicable diseasesTobacco use prevalenceRetirement Longitudinal StudySocio-economic inequalitiesPublic health policyPublic health controlRisk factorsLow educational attainmentHealth controlsChina HealthUse prevalenceHealth policyEducational attainmentOlder adultsUse quantityLongitudinal studyStrongest predictorPrevalenceAgeGenderSmokersIndexDisease
2012
Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients
Lin Z, Hegarty J, Yu W, Cappel J, Chen X, Faber P, Wang Y, Poritz L, Fan J, Koltun W. Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients. Digestive Diseases And Sciences 2012, 57: 3145-3153. PMID: 22821069, DOI: 10.1007/s10620-012-2288-z.Peer-Reviewed Original ResearchConceptsDNA methylationB cell linesReaction (PCR)-based restriction fragment length polymorphismCpG sitesCpG DNA methylation levelsComparison of methylation profilesDNA methylation lociRestriction fragment length polymorphismDNA methylation profilesLevel of gene expressionDNA methylation levelsDNA methylation markersPolymerase chain reaction (PCR)-based restriction fragment length polymorphismFragment length polymorphismInterleukin (IL)-12/IL-23 pathwayMethylation lociBeadArray dataMethylation changesMethylation profilesB cellsMethylation levelsLength polymorphismMethylation markersGene expressionMethylation status
2011
Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1
Yu W, Lin Z, Hegarty J, Chen X, Kelly A, Wang Y, Poritz L, Koltun W. Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1. Inflammation 2011, 35: 889-899. PMID: 21968973, DOI: 10.1007/s10753-011-9390-9.Peer-Reviewed Original ResearchConceptsNKX2-3B cellsCDNA microarrayUlcerative colitisCrohn's diseaseCell growthGenesCD patientsEGR1MRNA expressionNKX2CD pathogenesisDiseased intestinal tissueKnockdownChronic intestinal inflammationDisease patientsCrohn's disease patientsIntestinal inflammationIntestinal tissueUC patientsImmune responseCDNAPatientsMicroarrayColitisNKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells
Yu W, Hegarty J, Berg A, Chen X, West G, Kelly A, Wang Y, Poritz L, Koltun W, Lin Z. NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells. PLOS ONE 2011, 6: e20454. PMID: 21637825, PMCID: PMC3102722, DOI: 10.1371/journal.pone.0020454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell LineDemographyEndothelial CellsEndothelin-1FemaleGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksHomeodomain ProteinsHumansInflammatory Bowel DiseasesIntestinesMaleMicrovesselsMiddle AgedNitric Oxide Synthase Type IIIOligonucleotide Array Sequence AnalysisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, Small InterferingSignal TransductionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AConceptsInflammatory bowel disease pathogenesisHuman intestinal microvascular endothelial cellsNKX2-3CDNA microarrayIntestinal microvascular endothelial cellsGene expressionValidity of microarraysPI3KExpression levelsMicrovascular endothelial cellsRegulating endothelin-1Intestinal tissueRelated signaling pathwaysGene networksCellular functionsBiological functionsPathogenesis of inflammatory bowel diseaseInflammatory bowel diseasePathway analysisGenesSignaling pathwayMetabolic processesAssociated with inflammatory bowel diseaseVEGF signalingMRNA expression
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