2025
Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original ResearchAssociation of workforce participation with depression among US older adults: results from NHANES 2005–2018
Sun Z, Wang Y, Chen X, Qian D. Association of workforce participation with depression among US older adults: results from NHANES 2005–2018. BMC Geriatrics 2025, 25: 77. PMID: 39905307, PMCID: PMC11792604, DOI: 10.1186/s12877-025-05712-3.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyUS older adultsPHQ-9 scoresOlder adultsDepression riskLogistic regression modelsWorkforce participationPatient Health Questionnaire-9 itemsWork statusHealth and Nutrition Examination SurveyAnalysis of subgroupsRegular daytimeMethodsThis cross-sectional studyNutrition Examination SurveyPrevalence of depressionDecrease depression riskPotential reverse causationRegression modelsCross-sectional studyNon-linear associationInstrumental variablesPHQ-9Propensity score matchingExamination SurveyReverse causationExposure to School Racial Segregation and Late-Life Cognitive Outcomes
Lin Z, Wang Y, Gill T, Chen X. Exposure to School Racial Segregation and Late-Life Cognitive Outcomes. JAMA Network Open 2025, 8: e2452713. PMID: 39752159, PMCID: PMC11699536, DOI: 10.1001/jamanetworkopen.2024.52713.Peer-Reviewed Original ResearchConceptsCross-sectional studyCognitive scoresOlder adultsTelephone Interview for Cognitive StatusBlack participantsLate-life cognitive outcomesWhite participantsSchool racial segregationCognitive impairmentHealth and Retirement StudyNon-Hispanic whitePrevalence of cognitive impairmentAssociated with late-life cognitionEducational attainmentUS older adultsLikelihood of cognitive impairmentNon-Hispanic blacksLate-life cognitionCognitive outcomesNationally Representative SampleLater-life cognitionMultilevel regression analysisStudy of BlackDementia occurrenceHealth inequalities
2024
Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)
Chen S, Underwood B, Cardinal R, Chen X, Chen S, Amin J, Jin H, Huang J, Mueller C, Yan L, Brayne C, Kuper H. Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019). BMC Medicine 2024, 22: 268. PMID: 38926751, PMCID: PMC11210022, DOI: 10.1186/s12916-024-03464-2.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionModifiable risk factorsEnglish Longitudinal Study of AgeingOverall PAFLongitudinal Study of AgingEnglish Longitudinal StudyPhysical inactivitySocioeconomic statusStudy of agingLower educationDementia riskSocial isolationAttributable fractionHearing lossRisk factorsTargeted public health strategiesTraumatic brain injuryProportion of dementiaDeterminants of dementiaSocioeconomic status categoriesEffective public health policiesDevelopment of evidence-basedPublic health strategiesPublic health policiesTime-series study
2022
Difficulty and help with activities of daily living among older adults living alone during the COVID-19 pandemic: a multi-country population-based study
Chen S, Jones LA, Jiang S, Jin H, Dong D, Chen X, Wang D, Zhang Y, Xiang L, Zhu A, Cardinal RN. Difficulty and help with activities of daily living among older adults living alone during the COVID-19 pandemic: a multi-country population-based study. BMC Geriatrics 2022, 22: 181. PMID: 35246064, PMCID: PMC8894568, DOI: 10.1186/s12877-022-02799-w.Peer-Reviewed Original ResearchConceptsHealth system factorsADL assistanceOlder adultsCOVID-19 pandemicPopulation-based studyLongitudinal cohort studyHealth service expendituresSystem factorsCOVID-19Wealth-related inequalitiesHealth-related indicatorsPandemic-related changesCohort studyADL difficultyEligible peopleBackgroundOlder adultsDaily livingAdultsInternational variationConcentration indexService expendituresPandemicDifficulty statusSex gapUnequal response
2020
Barriers of effective health insurance coverage for rural-to-urban migrant workers in China: a systematic review and policy gap analysis
Chen S, Chen Y, Feng Z, Chen X, Wang Z, Zhu J, Jin J, Yao Q, Xiang L, Yao L, Sun J, Zhao L, Fung H, Wong EL, Dong D. Barriers of effective health insurance coverage for rural-to-urban migrant workers in China: a systematic review and policy gap analysis. BMC Public Health 2020, 20: 408. PMID: 32228665, PMCID: PMC7106835, DOI: 10.1186/s12889-020-8448-8.Peer-Reviewed Original ResearchConceptsUrban migrant workersEffective health insurance coverageMigrant workersJob stabilityDisadvantaged positionSocial welfare schemesChinese central governmentPolicy gap analysisHealth insurance schemeReluctance of employersChina’s total populationInsurance schemeMore vocational trainingCurrent health insurance schemesCentral governmentWelfare schemesSocial health insuranceWork mobilityLow job stabilityPolicy suggestionsVocational trainingHealthcare policyHealth insurance coverageHealth needsEmployersAttributable risk and economic cost of hospital admissions for mental disorders due to PM2.5 in Beijing
Wu Z, Chen X, Li G, Tian L, Wang Z, Xiong X, Yang C, Zhou Z, Pan X. Attributable risk and economic cost of hospital admissions for mental disorders due to PM2.5 in Beijing. The Science Of The Total Environment 2020, 718: 137274. PMID: 32109812, PMCID: PMC9429815, DOI: 10.1016/j.scitotenv.2020.137274.Peer-Reviewed Original ResearchConceptsHospital admissionAttributable riskMental disordersEconomic burdenSignificant risk increaseMental health statusEffects of PMSubstantial morbidityStratified analysisElderly individualsHealth statusMedical expensesStudy periodAir quality guidelinesRisk increaseAdmissionTime trendsRiskEconomic costsDisordersPossible correlationBurdenAerodynamic diameterExposureDaily increaseLinking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study
Li Y, Xue QL, Odden MC, Chen X, Wu C. Linking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study. Age And Ageing 2020, 49: 208-217. PMID: 31957780, PMCID: PMC7047816, DOI: 10.1093/ageing/afz160.Peer-Reviewed Original ResearchConceptsEarly life risk factorsLife risk factorsRisk factorsChildhood health statusRetirement Longitudinal StudyRisk differenceHealth statusChina HealthOlder ageOlder adultsAbsolute risk differenceCross-sectional studyLongitudinal studyUnfavorable socioeconomic statusLate-life frailtyWorse health conditionsChinese older adultsMiddle-income countriesDevelopment of diseaseHigh riskLower riskRepresentative cohortMultinomial regression modelsHealth conditionsFrailtyAssociations between prenatal sunshine exposure and birth outcomes in China
Zhang X, Wang Y, Chen X, Zhang X. Associations between prenatal sunshine exposure and birth outcomes in China. The Science Of The Total Environment 2020, 713: 136472. PMID: 31955080, PMCID: PMC7047502, DOI: 10.1016/j.scitotenv.2019.136472.Peer-Reviewed Original Research
2019
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS HealthDecomposing inequality in catastrophic health expenditure for self-reported hypertension household in Urban Shaanxi, China from 2008 to 2013: two waves’ cross-sectional study
Si Y, Zhou Z, Su M, Wang X, Lan X, Wang D, Gong S, Xiao X, Shen C, Ren Y, Zhao D, Hong Z, Bian Y, Chen X. Decomposing inequality in catastrophic health expenditure for self-reported hypertension household in Urban Shaanxi, China from 2008 to 2013: two waves’ cross-sectional study. BMJ Open 2019, 9: e023033. PMID: 31076467, PMCID: PMC6528006, DOI: 10.1136/bmjopen-2018-023033.Peer-Reviewed Original ResearchConceptsCatastrophic health expenditurePro-poor inequalityMixed householdsHealth expenditureIncome-related inequalitiesNational Health Services SurveyPocket healthcare expenditureHousehold economic statusFifth National Health Service SurveysHealthcare reformHealth Services SurveyCHE occurrenceHousehold capacityObserved inequalitiesProbit regressionUrban ChinaConcentration indexHouseholdsHealthcare expendituresEconomic statusChina's healthcare reformElderly membersExpenditureInequalityServices Survey
2018
Does money relieve depression? Evidence from social pension expansions in China
Chen X, Wang T, Busch SH. Does money relieve depression? Evidence from social pension expansions in China. Social Science & Medicine 2018, 220: 411-420. PMID: 30530234, PMCID: PMC6800113, DOI: 10.1016/j.socscimed.2018.12.004.Peer-Reviewed Original ResearchAssessing the effects of the percentage of chronic disease in households on health payment-induced poverty in Shaanxi Province, China
Lan X, Zhou Z, Si Y, Shen C, Fan X, Chen G, Zhao D, Chen X. Assessing the effects of the percentage of chronic disease in households on health payment-induced poverty in Shaanxi Province, China. BMC Health Services Research 2018, 18: 871. PMID: 30458772, PMCID: PMC6245518, DOI: 10.1186/s12913-018-3698-1.Peer-Reviewed Original ResearchConceptsHealth payment-induced povertyNational Health Services SurveyChronic patientsChronic diseasesChina National Health Services SurveyMore chronic diseasesNational Health SurveyHealth Services SurveyHeavy economic burdenLogistic regression modelsHealth paymentsHealth SurveyMethodsThe dataEconomic burdenPatientsFurther healthcare reformProtective factorsDiseaseIncidenceServices SurveyRural areasVulnerable groupsRegression modelsHealthcare reformHousehold membersSmog, Cognition and Real-World Decision-Making
Chen X. Smog, Cognition and Real-World Decision-Making. International Journal Of Health Policy And Management 2018, 8: 76-80. PMID: 30980620, PMCID: PMC6462201, DOI: 10.15171/ijhpm.2018.105.Peer-Reviewed Original ResearchConceptsCognitive test performanceHigh-stakes marketsCognition performanceCognitive functioningPsychological pathwaysCognitive testsTest performanceCognitive impairmentCognitionComplex decisionsDecision-making processDaily lifeEducational attainmentRich implicationsWindow of exposureEnvironmental stressorsFunctioningStressorsImpairmentSocial costsImplicationsAttainmentPerformanceGenderDecisionsSocio-Economic Inequalities in Tobacco Consumption of the Older Adults in China: A Decomposition Method
Si Y, Zhou Z, Su M, Wang X, Li D, Wang D, He S, Hong Z, Chen X. Socio-Economic Inequalities in Tobacco Consumption of the Older Adults in China: A Decomposition Method. International Journal Of Environmental Research And Public Health 2018, 15: 1466. PMID: 29997376, PMCID: PMC6069145, DOI: 10.3390/ijerph15071466.Peer-Reviewed Original ResearchConceptsTobacco consumptionConcentration indexNon-communicable diseasesTobacco use prevalenceRetirement Longitudinal StudySocio-economic inequalitiesPublic health policyPublic health controlRisk factorsLow educational attainmentHealth controlsChina HealthUse prevalenceHealth policyEducational attainmentOlder adultsUse quantityLongitudinal studyStrongest predictorPrevalenceAgeGenderSmokersIndexDiseaseAir pollution associated with non-suicidal self-injury in Chinese adolescent students: A cross-sectional study
Liu W, Sun H, Zhang X, Chen Q, Xu Y, Chen X, Ding Z. Air pollution associated with non-suicidal self-injury in Chinese adolescent students: A cross-sectional study. Chemosphere 2018, 209: 944-949. PMID: 30114744, PMCID: PMC6100799, DOI: 10.1016/j.chemosphere.2018.06.168.Peer-Reviewed Original Research
2012
Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients
Lin Z, Hegarty J, Yu W, Cappel J, Chen X, Faber P, Wang Y, Poritz L, Fan J, Koltun W. Identification of Disease-Associated DNA Methylation in B Cells from Crohn’s Disease and Ulcerative Colitis Patients. Digestive Diseases And Sciences 2012, 57: 3145-3153. PMID: 22821069, DOI: 10.1007/s10620-012-2288-z.Peer-Reviewed Original ResearchConceptsDNA methylationB cell linesReaction (PCR)-based restriction fragment length polymorphismCpG sitesCpG DNA methylation levelsComparison of methylation profilesDNA methylation lociRestriction fragment length polymorphismDNA methylation profilesLevel of gene expressionDNA methylation levelsDNA methylation markersPolymerase chain reaction (PCR)-based restriction fragment length polymorphismFragment length polymorphismInterleukin (IL)-12/IL-23 pathwayMethylation lociBeadArray dataMethylation changesMethylation profilesB cellsMethylation levelsLength polymorphismMethylation markersGene expressionMethylation status
2011
Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1
Yu W, Lin Z, Hegarty J, Chen X, Kelly A, Wang Y, Poritz L, Koltun W. Genes Differentially Regulated by NKX2-3 in B Cells Between Ulcerative Colitis and Crohn’s Disease Patients and Possible Involvement of EGR1. Inflammation 2011, 35: 889-899. PMID: 21968973, DOI: 10.1007/s10753-011-9390-9.Peer-Reviewed Original ResearchConceptsNKX2-3B cellsCDNA microarrayUlcerative colitisCrohn's diseaseCell growthGenesCD patientsEGR1MRNA expressionNKX2CD pathogenesisDiseased intestinal tissueKnockdownChronic intestinal inflammationDisease patientsCrohn's disease patientsIntestinal inflammationIntestinal tissueUC patientsImmune responseCDNAPatientsMicroarrayColitisNKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells
Yu W, Hegarty J, Berg A, Chen X, West G, Kelly A, Wang Y, Poritz L, Koltun W, Lin Z. NKX2-3 Transcriptional Regulation of Endothelin-1 and VEGF Signaling in Human Intestinal Microvascular Endothelial Cells. PLOS ONE 2011, 6: e20454. PMID: 21637825, PMCID: PMC3102722, DOI: 10.1371/journal.pone.0020454.Peer-Reviewed Original ResearchMeSH KeywordsAdultCell LineDemographyEndothelial CellsEndothelin-1FemaleGene Expression RegulationGene Knockdown TechniquesGene Regulatory NetworksHomeodomain ProteinsHumansInflammatory Bowel DiseasesIntestinesMaleMicrovesselsMiddle AgedNitric Oxide Synthase Type IIIOligonucleotide Array Sequence AnalysisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA, Small InterferingSignal TransductionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AConceptsInflammatory bowel disease pathogenesisHuman intestinal microvascular endothelial cellsNKX2-3CDNA microarrayIntestinal microvascular endothelial cellsGene expressionValidity of microarraysPI3KExpression levelsMicrovascular endothelial cellsRegulating endothelin-1Intestinal tissueRelated signaling pathwaysGene networksCellular functionsBiological functionsPathogenesis of inflammatory bowel diseaseInflammatory bowel diseasePathway analysisGenesSignaling pathwayMetabolic processesAssociated with inflammatory bowel diseaseVEGF signalingMRNA expression
2010
Identification of disease‐associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease
Lin Z, Hegarty J, Cappel J, Yu W, Chen X, Faber P, Wang Y, Kelly A, Poritz L, Peterson B, Schreiber S, Fan J, Koltun W. Identification of disease‐associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease. Clinical Genetics 2010, 80: 59-67. PMID: 20950376, DOI: 10.1111/j.1399-0004.2010.01546.x.Peer-Reviewed Original ResearchConceptsDNA methylationCpG sitesDifferentially methylated CpG sitesDNA methylation profilesLevel of gene expressionIBD-associated genesInflammatory bowel disease pathogenesisIntestinal tissueMethylation stateMultiple genesMethylation profilesMethylation assayPathogenesis of diseaseGene expressionInflammatory bowel diseaseEpigenetic factorsDNAGenetic predispositionGenesDisease subtype-specificAbnormal interactionsNon-diseaseEnvironmental factorsMethylationBowel disease
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